What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zykadia (Ceritinib)
Prescription Required
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Product Details
Description
Zykadia (ceritinib) is a medication that is prescribed to treat adults with non-small cell lung cancer that has spread to other parts of the body.
Zykadia is available in oral 150 mg capsules and tablets.
Fact Table
Formula
C28H36N5O3Cl
License
US FDA, EMA
Bioavailability
58%
Legal status
Prescription only
Chemical Name
Ceritinib
Elimination half-life
41 hours
Dosage (Strength)
150 mg, 450 mg, 750 mg tablets
Pregnancy
Consult a doctor
Brands
Zykadia
Protein binding
97%
PubChem CID
57379310
MedlinePlus
a614059
ChEBI
63629
ATC code
L01XE28
DrugBank
DB09055
KEGG
D10300
Routes of administration
Oral
Directions
Take Zykadia exactly as prescribed by your doctor. Carefully read the medication guide that comes with your prescription. Talk to your doctor or pharmacist about any questions or concerns you may have.
Recommended Zykadia dosing: 450 mg by mouth once daily. Take with food.
Keep Zykadia at room temperature between 68°F to 77°F (20°C to 25°C) and out of reach of children.
Ingredients
The active ingredient in Zykadia is ceritinib.
Inactive ingredients in the 150 mg capsules include colloidal silicon dioxide, hard gelatin capsule shells, low substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, FD&C Blue # 2, gelatin, and titanium dioxide.
Inactive ingredients in the 150 mg tablets include colloidal silicon dioxide, croscarmellose sodium, low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, povidone, FD&C Blue # 2 aluminum lake, hypromellose, polyethylene glycol 4000, talc, and titanium dioxide.
Contraindications
There are no contraindications to Zykadia per the most recent Prescribing Information.
Cautions
- Before you begin taking Zykadia, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Zykadia is associated with the following warnings and precautions:
- Gastrointestinal adverse reactions
- Liver problems
- Lung problems
- Abnormal heart rhythm (QT prolongation)
- High blood glucose
- Slow heart rate
- Pancreatitis
- Harm to an unborn baby. Effective contraception is recommended for females of childbearing age during treatment with Zykadia and for 6 months after taking the last dose. Condoms are recommended for males with female partners who are of childbearing age during treatment with Zykadia and for 3 months after the last dose.
Side Effects
Diarrhea, nausea, abdominal pain, vomiting, fatigue, decreased appetite, and weight loss are some common side effects associated with Zykadia; however, other side effects may also occur. Immediately inform your doctor of any side effects that bother you or won’t go away.
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Reference:
Zykadia. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14553
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