What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zolinza (Vorinostat)
Prescription Required
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Product Details
Description
Zolinza (vorinostat) is prescribed to treat a type of cancer called cutaneous T-cell lymphoma in patients whose cancer has progressed, won’t go away, or keeps coming back and are receiving two systemic treatments.
Zolinza is available in 100 mg oral capsules.
Fact Table
Formula
C14H20N2O3
License
US FDA
Bioavailability
43% (oral)
Legal status
Prescription only (Rx)
Chemical Name
Vorinostat
Elimination half-life
2 hours
Dosage (Strength)
100 mg capsules
Pregnancy
Contraindicated
Brands
Zolinza
Protein binding
71%
PubChem CID
5311
MedlinePlus
a607048
ChEBI
CHEBI:46755
ATC code
L01XX29
DrugBank
DB02546
KEGG
D06521
Routes of administration
Oral
Directions
Take Zolinza exactly as prescribed by your doctor. Your doctor will instruct you on how much medication you should take and for how long. For additional instructions for use, carefully read the medication guide that accompanies your prescription.
Recommended dosing: 400 mg by mouth one time a day with food. Dose adjustments may be required for patients who are intolerant to therapy or have liver problems.
Store Zolinza capsules between 20°C and 25°C (68°F and 77°F).
If you have any questions or concerns about Zolinza, contact your doctor or pharmacist.
Ingredients
The active ingredient in Zolinza capsules is vorinostat.
Inactive ingredients include microcrystalline cellulose, sodium croscarmellose, magnesium stearate, titanium dioxide, gelatin, and sodium lauryl sulfate.
Contraindications
There are no contraindications to Zolinza per the most recent Prescribing Information. However, talk to your doctor about whether Zolinza may be appropriate for you.
Cautions
- Before you begin treatment with Zolinza, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Zolinza is associated with the following warnings and precautions:
- Blood clots in the veins or lungs
- Reduced activity of the bone marrow, potentially causing low platelets and blood cell counts
- Nausea, vomiting, and diarrhea
- High blood glucose levels
- Abnormal electrolyte levels
- Severely low platelet counts with bleeding in the stomach and intestines
- Harm to an unborn baby. Females of childbearing potential should be advised to use effective contraceptive methods during Zolinza treatment and for 6 months or longer after receiving the last dose. Males with female partners who have the ability to reproduce should be advised to use effective contraceptive methods during Zolinza treatment and for 3 months or longer after receiving the last dose.
- Breastfeeding is not recommended during treatment with Zolinza and for one week or longer after receiving the last dose.
Side Effects
Diarrhea, nausea, fatigue, low platelets, anorexia, and altered taste are possible Zolinza side effects; however, other side effects may also occur. Immediately talk to your doctor about any side effects that bother you or won’t go away.
Looking for a competitive Zolinza price? You can buy 100 mg Zolinza capsules right here.
Reference
Zolinza. Rahway, NJ: Merck Sharp & Dohme LLC; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11999
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