What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zepatier (Elbasvir/Grazoprevir)
Prescription Required
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Product Details
Description
Zepatier (elbasvir and grazoprevir) is a prescription medication used to treat adults and pediatric patients who are at least 12 years old and weigh at least 30 kg with chronic hepatitis C virus genotype 1 or 4 infection. It may be used with ribavirin in certain patients.
Zepatier is available in an oral tablet containing 50 mg elbasvir and 100 mg grazoprevir.
Fact Table
Formula
C49H55N9O7•C38H50N6O9S
License
US FDA, EMA
Bioavailability
Elbasvir: Not specified, Grazoprevir: ~27% (oral)
Legal status
Prescription only
Chemical Name
Elbasvir: (1R,2S)-2-[(2S)-2-[[5-(4-bromophenyl)pyrrol-2-yl]carbonylamino]-3,3-dimethylbutanoylamino]-2-methyl-5-[4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenyl]-1,3-oxathiolane-4-carboxylic acid, Grazoprevir: [(1R,2S)-2-[(2S)-2-[[[(1S,4S)-2-[(cyclopropylsulfonyl)methyl]-4-(4-phenoxyphenyl)cyclopentyl]methyl]carbamoyl]pyrrolidin-1-yl]-1,3-thiazol-5-yl]carbamoyl]cyclopropanecarboxamide
Elimination half-life
Elbasvir: 24 hours, Grazoprevir: 31 hours
Dosage (Strength)
50 mg Elbasvir/100 mg Grazoprevir tablets
Pregnancy
Consult a doctor
Brands
Zepatier
Protein binding
Elbasvir: >99.9%, Grazoprevir: >98.8%
PubChem CID
Elbasvir: 71587255, Grazoprevir: 11978413
MedlinePlus
a616018
ChEBI
Elbasvir: CHEBI:90933, Grazoprevir: CHEBI:90932
ATC code
J05AP56
DrugBank
Elbasvir: DB11574, Grazoprevir: DB11575
KEGG
Elbasvir: D10853, Grazoprevir: D10855
Routes of administration
Oral
Directions
Zepatier should be taken as directed by your doctor. Your doctor will determine an appropriate treatment regimen for you.
The recommended dose is to take one tablet by mouth once daily; take with or without food.
Keep Zepatier stored in the original packaging between 20°C and 25°C (68°F and 77°F).
You may refer to the medication guide that comes with your prescription for further instructions for use.
Tell your doctor or pharmacist about any questions or concerns you have.
Ingredients
The active ingredients in Zepatier include elbasvir and grazoprevir.
Inactive ingredients include colloidal silicon dioxide, copovidone, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, mannitol, microcrystalline cellulose, sodium chloride, sodium lauryl sulfate, and vitamin E polyethylene glycol succinate. The film-coated tablets contain carnauba wax, ferrosoferric oxide, hypromellose, iron oxide red, iron oxide yellow, lactose monohydrate, titanium dioxide, and triacetin.
Contraindications
Patients with moderate to severe liver impairment should not take Zepatier.
Patients should not take OATP1B1/3 inhibitors that can significantly increase grazoprevir plasma concentrations, strong CYP3A4 inducers, and efavirenz while taking Zepatier. Ask your doctor whether you take these medications if you are unsure.
The contraindications to ribavirin also apply if you are also taking ribavirin. Talk to your doctor or pharmacist about any contraindications you may have.
Cautions
- Zepatier contains the following FDA Boxed Warning:
- Reactivation of hepatitis B virus has been reported and has resulted in, in some cases, fulminant liver inflammation, liver failure, and death.
- Before you begin taking Zepatier, inform your doctor of:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Zepatier medication contains the following warnings and precautions:
- Risk of hepatitis B virus reactivation
- Elevated liver function test (ALT)
- Risk of liver decompensation or failure in patients with evidence of advanced liver disease
- If you are also taking ribavirin, its warnings and precautions also apply; talk to your doctor or pharmacist about ribavirin’s warnings and precautions
Side Effects
Headache, fatigue, and nausea are common Zepatier side effects; however, other side effects may also occur.
Immediately inform your doctor of any side effects that bother you or won’t go away.
Searching for a price of Zepatier that’s competitive? With a valid prescription, you can buy Zepatier right here!
Reference
Zepatier. Rahway, NJ: Merck Sharp & Dohme LLC; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14588
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