What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zelboraf (Vemurafenib)
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Product Details
Description
Zelboraf (Vemurafenib) is a medicine used to treat melanoma, a type of skin cancer, especially when the cancer cannot be removed by surgery or has spread to other parts of the body. This drug specifically targets melanoma cells that have a certain change in their genes called the BRAF V600E mutation. By blocking the action of a protein called B-Raf, Vemurafenib helps cause cancer cells to die. It comes in the form of tablets, each containing 240 mg, which patients take by mouth. Besides melanoma, this medicine can also help treat a rare disease called Erdheim-Chester Disease in patients with the same BRAF V600 mutation.
Directions
Zelboraf is taken orally in tablet form. The typical starting dosage is 960 mg taken twice a day, separated by around 12 hours, with or without food. Follow the healthcare provider’s prescription instructions precisely. If a dose is missed, it should be taken as soon as remembered, unless it’s close to the time for the next dose. Doubling up doses is not recommended.
Ingredients
The active ingredient in Zelboraf is Vemurafenib.
Contraindications
There are no specific contraindications listed on the drug label. However, Zelboraf may not be suitable for everyone. Avoid taking or using this medication if you have a known hypersensitivity to Vemurafenib or any of its ingredients.
Cautions
- Before starting treatment with Zelboraf, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- Zelboraf can increase your risk of certain skin cancers like squamous cell carcinoma and melanoma. Have your skin checked by a doctor before starting treatment and every two months while you’re taking Zelboraf. Protect your skin from the sun by wearing sunscreen and protective clothing.
- Make sure you have the BRAF V600E mutation in your tumor before starting Zelboraf. This medication is specifically for treating cancers with this mutation.
- Zelboraf can affect your heart rhythm by prolonging the QT interval, which can lead to serious heart problems. If you have a history of heart issues or are taking other medications that affect your heart, discuss this with your doctor. Your heart rhythm and electrolyte levels will need to be monitored regularly.
- Zelboraf may cause your liver enzymes to rise, indicating possible liver stress or damage. Your doctor will monitor your liver function through blood tests. If you feel unusually tired, nauseous, or notice yellowing of your skin or eyes, contact your doctor immediately.
- This medication can make your skin more sensitive to sunlight, leading to severe sunburns even with short sun exposure. Use broad-spectrum sunscreen with at least SPF 30, wear protective clothing, and avoid prolonged time in the sun while taking Zelboraf.
- Zelboraf can cause vision problems such as blurry vision or sensitivity to light. If you experience any changes in your vision, stop taking Zelboraf and seek medical advice immediately.
- Zelboraf can harm an unborn baby. If you are pregnant or planning to become pregnant, use effective contraception during treatment and for two weeks after your last dose. Men with female partners who can become pregnant should use contraception during treatment and for three months after the last dose.
- If you are receiving radiation therapy, let your doctor know you are taking Zelboraf. Combining these treatments can cause severe reactions. Your doctor will monitor you closely to manage any issues that arise.
- Zelboraf can affect your kidneys. Your doctor will monitor your kidney function with blood tests. If you experience symptoms like decreased urine output or swelling, contact your doctor right away.
Side Effects
Common side effects of Zelboraf for melanoma treatment include joint pain (arthralgia), rash, hair loss (alopecia), and fatigue. You may also experience sensitivity to sunlight, nausea, itching (pruritus), and small skin growths called papillomas. These side effects are generally mild, but if they persist, it’s a good idea to speak with your healthcare provider.
For Erdheim-Chester Disease, side effects are more frequent and may include joint pain, maculo-papular rashes, and hair loss. Fatigue, prolonged QT intervals on an electrocardiogram, and skin papillomas are also common. If you notice any unusual heart symptoms, significant skin reactions, or experience prolonged fatigue, contact your healthcare provider for guidance.
References
- Zelboraf (Vemurafenib) Product Monograph. South San Francisco, CA: Genentech USA, Inc.; 2020.
- Zelboraf (Vemurafenib) Drug Label Information. South San Francisco, CA: Genentech USA, Inc.; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14631
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