Zavzpret (Zavegepant)
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Zavzpret (zavegepant) is a prescription nasal spray used to treat adults with migraines with or without aura. The medication should not be used to prevent migraines.
Zavzpret is available in a 10 mg nasal spray.
Fact Table
Formula
C29H28F3N5O2
License
US FDA
Bioavailability
Nasal: 5%
Legal status
Prescription only
Chemical Name
2-[(3S,5S)-5-{[2-fluoro-3-(trifluoromethyl)benzyl]oxy}pyrrolidin-3-yl]-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)pyridine-4-carboxamide
Elimination half-life
3.5 to 4 hours
Dosage (Strength)
10 mg/spray (intranasal)
Pregnancy
Consult a doctor
Brands
Zavzpret
Protein binding
~90%
PubChem CID
118906482
MedlinePlus
a623065
ChEBI
CHEBI:177195
ATC code
N02CD07
DrugBank
DB15184
KEGG
D11914
Routes of administration
Intranasal
Directions
Use Zavzpret nasal spray as directed.
The recommended dose is to inhale one spray in one nostril as needed. Do not use more than one dose in 24 hours. The safety of treating more than 8 migraines in a 30-day period has not been determined.
Avoid test spraying, priming, or pressing the plunger before use.
Using Zavzpret Nasal Spray
- Blow your nose gently.
- Take out one blister from the carton.
- Take out the device from the blister.
- Make sure the product has not expired. Properly discard if expired.
- Hold the device upright by putting your thumb on the bottom of the plunger and two fingers on each side of the nozzle.
- Close one nostril.
- Insert spray nozzle into the open nostril as much as you can comfortably.
- Keep your head level. Close your mouth. Slowly breathe in through your nose as you spray one time into the open nostril by pressing the plunger up with your thumb.
- Take the device out of your nostril and take your finger off your other nostril. Keep your head level for 20 seconds while breathing gently in through your nose and out through your mouth. If you feel dripping from your nose, sniff gently so you don’t lose any of the dose.
- Throw the used device into the trash.
Zavzpret should be stored at room temperature between 20°C and 25°C (68°F and 77°F) and out of reach of children. The medication should not be frozen.
For further instructions for use, you may refer to the medication guide that comes with your Zavzpret prescription.
Talk to your doctor or pharmacist about any questions or concerns you may have.
Ingredients
The active ingredient in Zavzpret is zavegepant.
Inactive ingredients include dextrose, hydrochloric acid, sodium hydroxide, and succinic acid in water for injection.
Contraindications
Patients with an allergy to zavegepant or to any of the other ingredients in the medication should avoid Zavzpret use.
Cautions
- Before you begin migraine treatment with Zavzpret, tell your doctor about:
- All the prescription and over-the-counter medications you take, including other migraine/headache medications or therapies
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Zavzpret may cause hypersensitivity reactions, including facial swelling and hives. Stop using Zavzpret and seek medical treatment if these reactions occur.
Side Effects
Problems with taste, nausea, nasal discomfort, and vomiting are common Zavzpret side effects. However, other side effects may also occur.
Tell your doctor right away if you have side effects that bother you or won’t go away.
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Reference
Zavzpret. New York, NY: Pfizer Inc.; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14943
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