What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zaroxolyn (Metolazone)
Prescription Required
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Product Details
Description
Zaroxolyn (metolazone) is a prescription medication used to treat edema, or swelling. It is also used to treat high blood pressure. The medication is classified as a diuretic, or fluid pill.
Zaroxolyn comes in 2.5 mg, 5 mg, and 10 mg tablets for oral administration.
Fact Table
Formula
C16H16ClN3O3S
License
US DailyMed
Bioavailability
65-75%
Legal status
Rx-only
Chemical Name
Metolazone
Elimination half-life
14 hours
Dosage (Strength)
2.5mg, 5mg
Pregnancy
Consult Doctor
Brands
Zaroxolyn is one of the brand names for metolazone. It may also be sold under other brand names.
Protein binding
Metolazone is moderately protein-bound, with approximately 40% to 50% binding to plasma proteins
PubChem CID
4170
MedlinePlus
a682345
ChEBI
64354
ATC code
C03BA08
DrugBank
DB00524
KEGG
D00431
Routes of administration
Metolazone is usually taken orally as a tablet
Directions
Take Zaroxolyn exactly as your doctor has prescribed. If you have any questions or concerns, talk to your doctor or pharmacist.
Zaroxolyn dose for high blood pressure:
Take 2.5 mg to 5 mg by mouth once daily, up to 20 mg a day.
Dosing for fluid retention:
2.5 mg to 10 mg by mouth once daily, up to 20 mg a day.
Older patients may need to take a lower dose.
Ingredients
The active ingredient in Zaroxolyn is metolazone.
Contraindications
Zaroxolyn should not be given to patients who are:
- Allergic to metolazone or sulfonamides
- Unable to produce urine
In addition, patients who are in a hepatic coma or precoma should not receive Zaroxolyn.Cautions
- Before you start taking Zaroxolyn, inform your doctor of:
- All the medications you take
- Your allergies
- Your current health conditions and past medical history
- Your pregnancy or breastfeeding status
- Any upcoming surgeries or procedures
- Patients with diabetes, high cholesterol, elevated uric acid levels or gout, low blood pressure, lupus, or liver disease should use Zaroxolyn with caution. Patients who have had a sympathectomy should also use Zaroxolyn with caution.
- Zaroxolyn can worsen digitalis toxicity.
- Zaroxolyn can cause photosensitivity.
- High calcium, low potassium, low sodium, and low magnesium levels can occur with Zaroxolyn use.
- Angioedema (swelling underneath the skin) or other allergic reactions can occur with Zaroloxyn use.
- Patients with a sulfa allergy may exhibit allergic reactions due to cross-sensitivity; however, this may not occur or the risk is low.
- Zaroxolyn can affect lipid and glucose metabolism.
- Males may experience sexual dysfunction during treatment with Zaroxolyn.
- Monitor for low blood pressure regularly, especially if you are also taking other blood pressure medications.
- Patients with primary adrenal insufficiency should avoid taking Zaroxolyn for the treatment of high blood pressure. Adjustments of glucocorticoid/mineralocorticoid therapy or an alternative blood pressure medication is recommended.
Side Effects
Some Zaroxolyn side effects include chest pain, depression, dizziness, drowsiness, electrolyte abnormalities, glucose in the urine, gout attacks, headache, liver problems, high uric acid levels, joint pain, nerve pain, low blood pressure, pancreatitis, serious skin problems, fainting, and volume depletion; however, other side effects can also occur. Call your doctor if you have side effects that are bothersome or persistent.
You can buy Zaroxolyn medication online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
Reference:
Metolazone. Medscape.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2403
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