What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zamine (Drospirenone - ethinyl estradiol)
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Generic Equivalent - Zamine (Drospirenone - ethinyl estradiol)
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Product Details
Description
Zamine (drospirenone and ethinyl estradiol) is a combination hormone medication used as a contraceptive or birth control method. It works by preventing ovulation, altering the cervical mucus, and changing the lining of the uterus, which makes it difficult for sperm to reach the egg for fertilization.Contraception/Birth Control
Fact Table
Formula
C18H24O4
License
US FDA, EU EMA
Bioavailability
high
Legal status
Rx-Only
Chemical Name
Drospirenone/estetrol
Elimination half-life
24–27 h
Dosage (Strength)
21 days, 28 days
Pregnancy
-
Brands
Zamine
Protein binding
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PubChem CID
27125
MedlinePlus
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ChEBI
142773
ATC code
G03AA18
DrugBank
DB01395
KEGG
D12047
Routes of administration
By mouth
Directions
21-day regimen: Take one pill at the same time every day for 21 days and then discontinue the medication for 7 days. Withdrawal bleeding typically starts within 2-3 days of stopping. The next course starts on the 8th day after discontinuation, and continues on the same weekday as the initial course began.
28-day regimen: Take an active tablet daily for 21 days, followed by a hormone-free white tablet for 7 days. Withdrawal bleeding typically happens within 2-3 days after the last yellow tablet. The next course begins immediately after the last one ends and continues on the same weekday as the first course began.
Ingredients
Each active pill of Zamine contains 3 mg of Drospirenone and 0.03 mg of ethinyl estradiol.
Contraindications
Do not use Zamine if you are allergic to Drospirenone, ethinyl estradiol, or any other ingredient in Zamine. You should also avoid Zamine if you have a history of any of the following:
- Blood clots or health conditions that increase the risk of blood clots
- Stroke or other cerebrovascular problems
- Heart attack
- Heart disease
- Severely high blood pressure
- Abnormal cholesterol levels
- Smoking
- Age over 35 years old
- Diabetes that affects the blood vessels
- Liver or kidney disease
- Pancreatitis
- Migraine with focal aura
- Breast or endometrial cancer
- Known or suspected pregnancy
Cautions
- Before you start using Zamine birth control, inform your doctor about any of the following:
- Any allergies you have.
- Any medications you take, including prescription, over-the-counter medications, and herbal supplements.
- Any health conditions you have, such as diabetes, migraines, or depression.
- If you are pregnant or plan to become pregnant.
- If you are nursing or plan to nurse your baby.
- Zamine may affect blood sugar levels. Monitor your blood sugar regularly if you have diabetes.
- Zamine may increase the risk of blood clots. Specific concerns include the potential for clotting disorders like vein inflammation, lung clots, stroke, heart-related clots, intestinal clots, and eye clots.
- Exercise caution if you are at risk for conditions that may lead to blood clotting, such as being immobilized after injuries or during prolonged illness. Use other non-hormonal birth control methods until you are back to your regular routine.
- Zamine may lead to visual impairments, either partial or total. If you experience any eye problems, such as swelling of the optic nerve or vascular issues within the eye, consult your healthcare provider immediately.
- If you suffer from severe headaches with no known cause or experience a worsening of existing migraines, inform your healthcare provider.
- If there's an increase in epileptic seizures, consult your healthcare provider.
- Zamine may increase your blood pressure. Check your blood pressure regularly and inform your healthcare provider of any high readings.
Side Effects
Zamine side effects may include nausea, vomiting, bloating, headache, breast tenderness, swelling of ankles/feet, weight changes, and changes in menstrual periods. Call your doctor right away if you experience any side effects that worsen or won’t go away, such as lumps in the breast, sudden heavy bleeding, severe abdominal pain, persistent nausea/vomiting, dark urine, or yellowing eyes/skin. Seek immediate medical help if you suspect an allergic reaction, experience symptoms of a blood clot, or notice any other severe reactions.
References:
Zamine Product Monograph. Toronto, ON: Apotex, Inc.; 2015.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13912
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