Xpovio (Selinexor)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Xpovio (selinexor) is a medication that is prescribed with other medications to treat adults who have multiple myeloma. It may also be used to treat adults who have relapsed or refractory diffuse large B-cell lymphoma.
Xpovio is available in 20 mg, 40 mg, 50 mg, and 60 mg oral tablets.
Fact Table
Formula
C17H11F6N7O
License
US FDA
Bioavailability
60–80% (oral)
Legal status
Prescription only
Chemical Name
(Z)-3-[3,5-Bis(trifluoromethyl)phenyl]-N'-[pyrazin-2-yl]-acrylohydrazide
Elimination half-life
6 to 8 hours
Dosage (Strength)
20 mg tablets
Pregnancy
Consult a doctor
Brands
Xpovio
Protein binding
95%
PubChem CID
25141694
MedlinePlus
a619023
ChEBI
CHEBI:133019
ATC code
L01XX61
DrugBank
DB12020
KEGG
D10624
Routes of administration
Oral
Directions
Take Xpovio exactly as prescribed by your doctor. Your doctor will determine an appropriate dose for you. Xpovio is typically taken one or two times a week.
Store Xpovio tablets at 30°C (86°F) or less; keep away from children’s reach.
For additional instructions for use, refer to the medication guide that accompanies your prescription.
If you have any questions or concerns, contact your doctor or pharmacist.
Ingredients
The active ingredient in Xpovio is selinexor.
Inactive ingredients include colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, Opadry 200 clear, Opadry II blue, povidone K30, and sodium lauryl sulfate.
Contraindications
According to the most recent Prescribing Information, there are no contraindications to taking Xpovio.
Cautions
- Before you begin treatment with Xpovio, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Xpovio is associated with the following warnings and precautions:
- Low platelet counts
- Low neutrophil counts
- Gastrointestinal toxicity, leading to nausea, vomiting, diarrhea, anorexia, and weight loss
- Low blood sodium levels
- Infections that may become serious
- Neurological problems; avoid driving and participating in other hazardous activities until you know how the medication affects you
- Harm to an unborn baby; females who are capable of reproducing and males with female partners who are capable of reproducing should be advised to use effective birth control methods during Xpovio treatment and for 1 week after taking the last dose
- Cataracts
- Women should be advised to not breastfeed
Side Effects
Fatigue; appetite loss; nausea; vomiting; diarrhea; upper respiratory tract infection; nerve problems that can cause pain, numbness, or tingling; weight loss; cataracts; low platelets; low blood sodium levels; low blood phosphate levels; low neutrophils, leukocytes, and lymphocytes; constipation; anemia; fever; and shortness of breath are common Xpovio side effects. Other side effects can also occur. Immediately notify your doctor of any side effects that bother you or won’t go away.
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Reference
Xpovio. Newton, MA: Karyopharm Therapeutics Inc.; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13773
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