What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Xeomin (IncobotulinumtoxinA)
Prescription Required
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Product Details
Description
Xeomin (incobotulinumtoxinA) is an injectable medication used to treat or improve:
- Chronic sialorrhea in patients who are least 2 years old
- Upper limb spasticity in adults
- Upper limb spasticity (except spasticity caused by cerebral palsy) in pediatric patients who are between 2 and 17 years old
- Cervical dystonia in adults
- Blepharospasm in adults
- The appearance of moderate to severe frown lines between the eyebrows with corrugator and/or procerus muscle activity in adults
Xeomin may be given intramuscularly or by intraglandular route.
Fact Table
Formula
C6760H10447N1743O2010S32
License
US FDA, EMA
Bioavailability
Local effect only (no systemic bioavailability)
Legal status
Prescription only (Rx)
Chemical Name
IncobotulinumtoxinA
Elimination half-life
Estimated 18-24 hours
Dosage (Strength)
50 units, 100 units per vial (injection)
Pregnancy
Consult a doctor
Brands
Xeomin
Protein binding
N/A (acts locally at neuromuscular junctions)
PubChem CID
117048383
MedlinePlus
a611011
ChEBI
CHEBI:133087
ATC code
M03AX01
DrugBank
DB00083
KEGG
D00959
Routes of administration
Intramuscular, intradermal injection
Directions
Xeomin may be given intramuscularly or intraglandular by a healthcare professional.
If you have any questions or concerns, talk to your or your child’s healthcare provider.
Ingredients
The active ingredient in Xeomin is incobotulinumtoxinA.
Inactive ingredients include human albumin and sucrose.
Contraindications
Patients who have an infection at the injection sites or who are allergic to botulinum neurotoxin type A or to any of the excipients in Xeomin should not receive it.
Cautions
- Xeomin contains the following FDA Boxed Warning:
- Xeomin’s effects, as well as all botulinum toxin product’s effects, can spread from the injection site to produce symptoms that are consistent with botulinum toxin effects. These symptoms may occur hours to weeks after receiving the injection. Trouble swallowing and breathing can be life threatening; death can also occur. Children treated for spasticity seem to be at greatest risk; however, adults may also experience symptoms, especially those with underlying conditions that would make them more susceptible to these symptoms.
- Before you or your child begins receiving Xeomin injections, talk to the healthcare provider about:
- All the prescription and over-the-counter medications you or your child takes
- Your or your child’s allergies
- Your or your child’s current health problems and past medical history
- Your or your child’s pregnancy or breastfeeding status
- Xeomin contains the following warnings and precautions:
- Trouble breathing, speaking, or swallowing
- Corneal exposure and ulceration
- Risk of ptosis, or drooping of the upper eyelid
- Xeomin’s potency units are not interchangeable with other botulinum toxin products
Side Effects
- Xeomin contains the following FDA Boxed Warning:
- Xeomin’s effects, as well as all botulinum toxin product’s effects, can spread from the injection site to produce symptoms that are consistent with botulinum toxin effects. These symptoms may occur hours to weeks after receiving the injection. Trouble swallowing and breathing can be life threatening; death can also occur. Children treated for spasticity seem to be at greatest risk; however, adults may also experience symptoms, especially those with underlying conditions that would make them more susceptible to these symptoms.
- Before you or your child begins receiving Xeomin injections, talk to the healthcare provider about:
- All the prescription and over-the-counter medications you or your child takes
- Your or your child’s allergies
- Your or your child’s current health problems and past medical history
- Your or your child’s pregnancy or breastfeeding status
- Xeomin contains the following warnings and precautions:
- Trouble breathing, speaking, or swallowing
- Corneal exposure and ulceration
- Risk of ptosis, or drooping of the upper eyelid
- Xeomin’s potency units are not interchangeable with other botulinum toxin products
Side Effects
The most common Xeomin side effects in patients receiving the injections for treating or improving:
- Chronic sialorrhea in adults: tooth extraction, dry mouth, diarrhea, and high blood pressure
- Chronic sialorrhea in pediatric patients: bronchitis, headache, nausea, and vomiting
- Upper limb spasticity in adults: seizure, nasopharyngitis, dry mouth, and upper respiratory tract infection
- Upper limb spasticity in pediatric patients: bronchitis and nasopharyngitis
- Cervical dystonia: trouble swallowing, neck pain, muscle weakness, pain at the injection site, musculoskeletal pain
- Blepharospasm: eyelid drooping, dry eye, vision problems, and dry mouth
- Frown lines between the eyebrows: headache
Immediately notify the health care provider of any side effects that bother you or your child or they persist.
Ask your or your child’s healthcare provider about Xeomin.
Reference
Xeomin. Raleigh, NC and Franksville, WI: Merz Pharmaceuticals, LLC and Merz North America, Inc.; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11676
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