What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Xatmep (Methotrexate)
Prescription Required
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Product Details
Description
Xatmep is an oral treatment for the cancer Acute Lymphoblastic Leukemia (ALL) and certain types of juvenile arthritis.
Fact Table
Formula
C20H22N8O5
License
US FDA, EU EMA
Bioavailability
60% at lower doses, less at higher doses
Legal status
Rx-Only
Chemical Name
Methotrexate
Elimination half-life
3–10 hours (lower doses), 8–15 hours (higher doses)
Dosage (Strength)
2.25mg
Pregnancy
Not Advised
Brands
Trexall, Rheumatrex, Otrexup
Protein binding
35–50% (parent drug), 91–93% (7-hydroxymethotrexate)
PubChem CID
126941
MedlinePlus
a682019
ChEBI
44185
ATC code
L01BA01
DrugBank
DB00563
KEGG
D00142
Routes of administration
By mouth, intravenous (IV), intramuscular (IM), subcutaneous injection (SC), intrathecal
Directions
Take Xatmep as prescribed by your doctor. Each person will have a unique dose that is adjusted for them.
Ingredients
The active ingredient in Xatmep is methotrexate.
Interactions
Common drug-drug interactions may include:
- Abrocitinib
- Acitretin
- Alcohol
- Baricitinib
- BCG Products
- Cladribine
- Coccidioides immitis Skin Test
- COVID-19 Vaccine
- Deferiprone
- Dengue Tetravalent Vaccine
- Denosumab
- Dexketoprofen
- Dichlorphenamide
- Dipyrone
- Echinacea
- Fexinidazole
- Foscarnet
- Influenza Virus Vaccines
- Inhibitors of the Proton Pump
- Leflunomide
- Lenograstim
- Lipegfilgrastim
- Natalizumab
- Nitrous Oxide
- Nonsteroidal Anti-Inflammatory Agents
- Palifermin
- Pimecrolimus
- Poliovirus Vaccine
- Polymethylmethacrylate
- Probenecid
- Rabies Vaccine
- Ropeginterferon Alfa-2b
- Rubella- or Varicella-Containing Live Vaccines
- Ruxolitinib
- Salicylates
- Sipuleucel-T
- Sulfonamide Antibiotics
- Tacrolimus
- Talimogene Laherparepvec
- Tertomotide
- Tofacitinib
- Trimethoprim
- Typhoid Vaccine
- Upadacitinib
- Yellow Fever Vaccine
Cautions
Use caution if you are planning to become pregnant.
Immunizations may not be effective while taking Xatmep.
Secondary malignancies may occur on Xatmep.
Side Effects
Common adverse reactions may include:
- Abdominal distress
- Abnormal cranial sensation
- Acne vulgaris
- Agranulocytosis
- Alopecia
- Anemia
- Anorexia
- Aphasia
- Aphthous
- Aplastic
- Arterial thrombosis
- Arthralgia
- Azotemia
- Blurred vision
- Bone fracture
- Bone marrow depression
- Burning sensation of the skin
- Cerebral thrombosis
- Chemical arachnoiditis chills
- Chest pain
- Chronic obstructive pulmonary disease
- Cognitive dysfunction
- Conjunctivitis
- Cough
- Cryptococcosis
- Cystitis
- Cytomegalovirus disease
- Decreased libido
- Decreased serum albumin
- Deep vein thrombosis
- Defective oogenesis
- Defective spermatogenesis
- Dermal ulcer
- Dermatitis
- Diabetes mellitus
- Diaphoresis
- Diarrhea
- Dizziness
- Drowsiness
- Dysarthria
- Dyschromia
- Dysuria
- Ecchymoses
- Enteritis
- Eosinophilia
- Epistaxis
- Erythema multiforme
- Erythematous rash
- Exacerbation of psoriasis
- Exfoliative dermatitis
- Eye pain
- Fatigue
- Fever
- Furunculosis
- Gastrointestinal hemorrhage
- Gastrointestinal ulcer
- Gingivitis
- Gynecomastia
- Headache
- Hematemesis
- Hematuria
- Hemiparesis
- Hepatic failure
- Hepatitis
- Herpes simplex infection
- Herpes zoster
- Histoplasmosis
- Hypogammaglobulinemia
- Hypotension
- Impotence
- Increased liver enzymes
- Infection
- Infertility
- Interstitial pneumonitis
- Intestinal perforation
- Leukoencephalopathy
- Leukopenia
- Lymphadenopathy
- Lymphoproliferative disorder
- Malaise
- Malignant lymphoma
- Melena
- Menstrual disease
- Mood changes
- Myalgia
- Myelopathy
- Nausea
- Neutropenia
- Nocardiosis
- Nodule
- Non-Hodgkin's lymphoma
- Non Immune anaphylaxis
- Oligospermia
- Osteonecrosis
- Osteoporosis
- Pancreatitis
- Pancytopenia
- Paresis
- Pericardial effusion
- Pericarditis
- Pharyngitis
- Pneumonia
- Polyarticular juvenile idiopathic arthritis
- Proteinuria
- Pruritus
- Psoriasis
- Pulmonary alveolitis
- Pulmonary embolism
- Pulmonary fibrosis
- Respiratory failure
- Retinal thrombosis
- Rheumatoid arthritis
- Seizure
- Sepsis
- Severe neurotoxicity
- Skin necrosis
- Skin photosensitivity
- Skin rash
- Speech disturbance
- Stevens-Johnson syndrome
- Stomatitis
- Stomatitis
- Thrombocytopenia
- Thrombophlebitis
- Tinnitus
- Tissue necrosis
- Transient blindness
- Tumor lysis syndrome
- Upper respiratory tract infection
- Vaccinia
- Vaginal discharge
- Vasculitis
- Vomiting
References
Xatmep. Greenwood Village, CO: Silvergate Pharmaceuticals, Inc.; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13635
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