What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vosevi (Sofosbuvir/Velpatasvir/Voxilaprevir)
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Product Details
Description
Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) is a medication prescribed to treat chronic hepatitis C virus (HCV) infection in adults.
Vosevi is available in oral tablets that contain 400 mg sofosbuvir, 100 mg velpatasvir, and 100 mg voxilaprevir.
Fact Table
Formula
C22H29FN3O9 (Sofosbuvir) + C49H54F2N8O8 (Velpatasvir) + C20H18F3N3O3 (Voxilaprevir)
License
US FDA, EMA
Bioavailability
Varies by component; food increases bioavailability
Legal status
Prescription only (Rx)
Chemical Name
Sofosbuvir, Velpatasvir, Voxilaprevir
Elimination half-life
Sofosbuvir: 0.4 hours; Velpatasvir: 15 hours; Voxilaprevir: 33 hours
Dosage (Strength)
400 mg Sofosbuvir, 100 mg Velpatasvir, 100 mg Voxilaprevir per tablet
Pregnancy
Consult a doctor
Brands
Vosevi
Protein binding
Sofosbuvir: 61-65%; Velpatasvir: >99.5%; Voxilaprevir: >99%
PubChem CID
Sofosbuvir: 45375808; Velpatasvir: 67683367; Voxilaprevir: 71586572
MedlinePlus
a617057
ChEBI
Sofosbuvir: CHEBI:85083; Velpatasvir: CHEBI:134722; Voxilaprevir: CHEBI:134719
ATC code
J05AP57
DrugBank
Sofosbuvir: DB08934; Velpatasvir: DB11613; Voxilaprevir: DB11759
KEGG
D10813
Routes of administration
Oral
Directions
Take Vosevi exactly how your doctor tells you to. Your doctor will determine an appropriate dose for you.
The recommended dose is to take one tablet by mouth once daily with food. If you take an antacid that contains magnesium or aluminum, wait to take it 4 hours before or 4 hours after taking Vosevi.
Keep Vosevi tablets in their original container at temperatures below 30°C (86°F) and away from children’s reach.
For additional information about Vosevi use, refer to the medication guide that comes with your prescription.
If you have any questions or concerns, reach out to your doctor or pharmacist.
Ingredients
The active ingredients in Vosevi are sofosbuvir, velpatasvir, and voxilaprevir.
Inactive ingredients include colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.The tablet film-coat contains ferrosoferric oxide, iron oxide red, iron oxide yellow, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.
Contraindications
Patients should not take Vosevi with rifampin.
Cautions
- Vosevi is associated with the following FDA Boxed Warning:
- Hepatitis B reactivation has occurred and may result in liver inflammation, liver failure, and death.
- Before you begin treatment with Vosevi, tell your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Vosevi is associated with a risk of hepatitis B virus reactivation.
- A low heart rate that can cause symptoms may occur when taking amiodarone with Vosevi.
Side Effects
Headache, fatigue, diarrhea, and nausea are the most common Vosevi side effects. Patients may also experience other side effects; therefore, contact your doctor if you develop side effects that bother you or won’t go away.
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References
- Vosevi. Foster City, CA: Gilead Sciences, Inc.; 2019.
- Vosevi. Foster City, CA: Gilead Sciences, Inc.; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14605
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