Description
Voquezna is a medication prescribed primarily for the treatment of stomach conditions, such as gastroesophageal reflux disease (GERD) and peptic ulcers. As a potassium-competitive acid blocker (P-CAB), it inhibits stomach acid production, which helps alleviate symptoms like heartburn, acid reflux, and ulcers.
Fact Table |
Formula |
C17H16FN3O2S |
License |
US FDA, PMDA |
Bioavailability |
~51% |
Legal status |
Prescription only (Rx) |
Chemical Name |
1-[5-(2-Fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl]-N-methylmethanamine |
Elimination half-life |
7.7 hours |
Dosage (Strength) |
10 mg, 20 mg tablets |
Pregnancy |
Consult a doctor |
Brands |
Voquezna, Takecab |
Protein binding |
80% |
PubChem CID |
44484724 |
MedlinePlus |
a622012 |
ChEBI |
CHEBI:134722 |
ATC code |
A02BC08 |
DrugBank |
DB12274 |
KEGG |
D09708 |
Routes of administration |
Oral |
Directions
The usual dosage is 10-20 mg, taken orally once daily.
The duration of treatment varies based on the specific condition for which Voquezna is prescribed.
Take the medication with or without food. Swallow tablets whole; do not chew, crush, or break them.
Ingredients
The active ingredient in Voquezna is vonoprazan.
Interactions
The most common drug-drug interactions may include:
- Abemaciclib
- Acalabrutinib
- Alfentanil
- Amiloride
- Apalutamide
- Astemizole
- Atazanavir
- Avacopan
- Axitinib
- Bedaquiline
- Bemetizide
- Bendroflumethiazide
- Benzhydrocodone
- Benzthiazide
- Bosentan
- Bosutinib
- Brigatinib
- Budesonide
- Bumetanide
- Canrenoate
- Canrenone
- Carbamazepine
- Cenobamate
- Ceritinib
- Chlorothiazide
- Chlorthalidone
- Cilostazol
- Cisapride
- Citalopram
- Clindamycin
- Clopamide
- Clopidogrel
- Cobimetinib
- Codeine
- Colchicine
- Conivaptan
- Crizotinib
- Cyclopenthiazide
- Cyclosporine
- Cyclothiazide
- Dabrafenib
- Dasatinib
- Diazoxide
- Digoxin
- Dihydrocodeine
- Dihydroergotamine
- Dipyrone
- Docetaxel
- Dofetilide
- Dronedarone
- Efavirenz
- Elagolix
- Entrectinib
- Enzalutamide
- Eplerenone
- Ergotamine
- Ethacrynic Acid
- Etozolin
- Etravirine
- Everolimus
- Fentanyl
- Flibanserin
- Fosphenytoin
- Furosemide
- Hydrochlorothiazide
- Hydrocodone
- Hydroflumethiazide
- Indapamide
- Ivosidenib
- Levomethadyl
- Lomitapide
- Lorlatinib
- Lumacaftor
- Mavacamten
- Meperidine
- Methadone
- Methyclothiazide
- Metolazone
- Midostaurin
- Mitotane
- Modafinil
- Nafcillin
- Nelfinavir
- Neratinib
- Nilotinib
- Olaparib
- Oxycodone
- Paclitaxel
- Pazopanib
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Piretanide
- Polythiazide
- Primidone
- Quinethazone
- Quinidine
- Quinine
- Ribociclib
- Rifabutin
- Rifampin
- Rifapentine
- Roflumilast
- Ruxolitinib
- Sirolimus
- Sonidegib
- Spironolactone
- St John's Wort
- Sufentanil
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telotristat Ethyl
- Temsirolimus
- Thioridazine
- Tolvaptan
- Torsemide
- Tramadol
- Triamterene
- Trichlormethiazide
- Warfarin
- Xipamide
- Zanubrutinib
Cautions
Before beginning Voquezna, inform your doctor if you have any history of liver disease, osteoporosis, or low magnesium levels.
Pregnant or breastfeeding women should consult with their healthcare provider before using Voquezna, as its safety during pregnancy and breastfeeding is not fully known.
Avoid using Voquezna if you are allergic to vonoprazan or any other ingredients in the medication.
Side Effects
The most common side effects of this drug may include:
- Abdominal distension symptom
- Abdominal pain
- Anaphylaxis
- Candidiasis, Vulvovaginal
- Constipation
- Diarrhea
- Gastritis
- Headache
- Hypertension
- Indigestion
- Liver failure
- Nausea
- Nasopharyngitis
- Respiratory
- Stevens-Johnson syndrome
- Taste sense altered
- Toxic epidermal necrolysis
- Tubulointerstitial nephritis, acute
- Urinary tract infectious disease
References
Voquezna [package insert]. Buffalo Grove, IL: Phathom; 2023.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 14895