What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Voltaren (Diclofenac) Suppositories
Generic Equivalent - Voltaren (Diclofenac) Suppositories
Prescription Required
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Product Details
Description
Voltarol suppositories contain diclofenac sodium, which is a non-steroidal anti-inflammatory drug (NSAID). These suppositories work by reducing inflammation and pain in the body. Doctors typically prescribe them for various conditions that involve pain and swelling, such as arthritis. By inserting these suppositories rectally, the medication absorbs into the body to help alleviate discomfort and inflammation.
Fact Table
Formula
C14H11Cl2NO2
License
US FDA, Health Canada
Bioavailability
Greater than 90% (rectal)
Legal status
Prescription only (Rx)
Chemical Name
2-(2,6-dichloranilino) phenylacetic acid
Elimination half-life
1–2 hours
Dosage (Strength)
12.5 mg, 25 mg, 50 mg, 100 mg (rectal suppository)
Pregnancy
Consult a doctor (especially during the third trimester)
Brands
Voltaren, Voltarol
Protein binding
99.7%
PubChem CID
3033
MedlinePlus
a689002
ChEBI
50177
ATC code
M02AA15
DrugBank
DB00586
KEGG
D07854
Routes of administration
Rectal
Directions
Voltaren suppositories are administered rectally and should only be used as directed by a healthcare professional. The dose of Voltaren suppositories may vary depending on the condition being treated, but it often ranges from 75 mg to 150 mg, divided into two or three doses per day. Patients usually start with a lower dose, which may be adjusted as needed.
To use, first remove the wrapper and moisten the suppository with water. Lie on your side and gently insert the suppository into the rectum, pointed end first, making sure it is well inside. Remain lying down for a few minutes to ensure the suppository stays in place. Hand hygiene is important both before and after insertion to prevent infection.
Ingredients
Voltaren suppositories contain diclofenac sodium as the active ingredient.
Contraindications
Avoid taking or using this medication if any of the following apply:
- Known allergy to diclofenac or any other NSAIDs.
- An active or history of recurring peptic ulcers or gastrointestinal bleeding.
- Severe liver or kidney disease.
- History of heart disease, such as heart failure or severe heart disease.
- Current or recent treatment with other NSAIDs.
- Third trimester of pregnancy.
Cautions
- Before starting treatment with Voltaren Suppositories, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- Regular reviews are necessary if you're on long-term Voltaren treatment to assess effectiveness, side effects, and ongoing necessity. Monitoring of blood pressure, hemoglobin levels, and kidney function may be required.
- Voltaren may increase the risk of severe cardiovascular events such as heart attacks and strokes, especially with prolonged use or higher doses. It's generally not recommended if you've had a heart attack in the last year, or if you have heart disease or uncontrolled hypertension.
- The use of Voltaren can lead to new or worsened hypertension, which can increase the risk of cardiovascular events. Blood pressure should be monitored regularly after starting Voltaren.
- Voltaren can cause fluid retention and edema, which may worsen heart failure. Caution is advised if you have heart conditions.
- Gastrointestinal risks like bleeding, ulceration, or perforation can occur without warning. This risk may increase with longer use or higher doses, especially in the elderly. Discontinue Voltaren if severe gastrointestinal bleeding occurs.
- Voltaren can also cause serious skin reactions, even without prior exposure. Be alert for symptoms such as skin rashes or blisters and discontinue use immediately if they appear.
- NSAIDs like Voltaren may mask the signs of infections. Be cautious if you have conditions like asthma or COPD, as Voltaren could worsen these.
- Liver function may be affected, and Voltaren should be used with caution in patients with liver disorders. Regular liver function tests are recommended.
- Voltaren may impair kidney function, especially in patients with existing kidney issues or in those taking medications that affect kidney function. Regular monitoring of kidney function is advisable.
- Be aware of potential blood-related effects such as changes in platelet function and other blood cell counts. Regular monitoring is recommended during long-term use.
- Special caution is advised for elderly patients, who may be more susceptible to adverse effects. The lowest effective dose should be used for these individuals.
Side Effects
Voltaren Suppositories generally cause mild side effects like stomach pain, heartburn, nausea, vomiting, and headache. Some people might experience dizziness, diarrhea, or a rash. Skin irritation or burning might occur at the insertion site.
Rare but serious side effects require immediate medical attention:
- Sudden chest pain, which could indicate a heart attack.
- Breathlessness or swelling of the feet, possible signs of heart failure.
- Symptoms such as sudden weakness, confusion, severe headaches, or changes in vision could signal a stroke.
- Severe stomach pain or signs of internal bleeding, like blood in your stool or when vomiting.
- Allergic reactions, which might include skin rashes, swelling of the face or throat, or severe itching.
- Yellowing of your skin or the whites of your eyes, which could suggest liver issues.
- Unusual changes in the amount or appearance of urine, possibly pointing to kidney problems.
References
- Voltaren (Diclofenac) Suppositories Data Sheet. Newmarket, Auckland: Novartis New Zealand Limited; 2022.
- Voltaren (Diclofenac) Suppositories Drug Label Information. London, UK: Novartis Pharmaceuticals UK Limited; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11592
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