What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vitrakvi (Larotrectinib)
Prescription Required
We don't have this generic product yet!
Sign up to get exclusive coupon discounts and be the first to be notified when we have this product available.
-
Product Details
Description
Vitrakvi is a prescription medication for certain types of cancer. It is specifically indicated for metastatic solid tumors with neurotrophic receptor tyrosine kinase (NTRK) gene fusion, without a known acquired resistance mutation, and with no alternative treatments.
Vitrakvi is a selective TRK inhibitor that targets and inhibits the activity of tropomyosin receptor kinases (TRKs), which are involved in the growth and proliferation of cancer cells with NTRK gene fusions. Vitrakvi stops cancer cells from growing and spreading by blocking TRK activity.
Fact Table
Formula
C21H22F2N6O2
License
US FDA, EMA
Bioavailability
34%
Legal status
Prescription only (?)
Chemical Name
(3S)-N-{5-[(2,5-Difluorophenyl)methyl]-1H-pyrazol-3-yl}-3-(1-methylpyrazol-4-yl)benzamide
Elimination half-life
2.9 hours
Dosage (Strength)
25 mg, 100 mg capsules; 20 mg/mL oral solution
Pregnancy
Use with caution
Brands
Vitrakvi
Protein binding
70-80%
PubChem CID
50920634
MedlinePlus
a619025
ChEBI
CHEBI:133003
ATC code
L01XE56
DrugBank
DB11986
KEGG
D11019
Routes of administration
Oral
Directions
The typical dose for adults and pediatric patients is 100 mg orally twice daily. If necessary, your doctor may recommend an adjustment.
Ingredients
The active ingredient in Vitrakvi is larotrectinib.
Interactions
Common drug-drug interactions include:
- Abametapir
- Acalabrutinib
- Alfentanil
- Alprazolam
- Amiodarone
- Apalutamide
- Aprepitant
- Atazanavir
- Avanafil
- Avapritinib
- Boceprevir
- Bosentan
- Bosutinib
- Budesonide
- Buprenorphine
- Buspirone
- Carbamazepine
- Cenobamate
- Ciprofloxacin
- Clarithromycin
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Conivaptan
- Crizotinib
- Cyclosporine
- Darifenacin
- Darunavir
- Dasatinib
- Dihydroergotamine
- Diltiazem
- Dronedarone
- Efavirenz
- Eletriptan
- Entrectinib
- Enzalutamide
- Eplerenone
- Erythromycin
- Etravirine
- Everolimus
- Fedratinib
- Felodipine
- Fentanyl
- Fexinidazole
- Finerenone
- Fluconazole
- Fluticasone
- Fosaprepitant
- Fosnetupitant
- Fosphenytoin
- Ibrexafungerp
- Ibrutinib
- Idelalisib
- Imatinib
- Indinavir
- Itraconazole
- Ivabradine
- Ivacaftor
- Ketoconazole
- Lemborexant
- Letermovir
- Lomitapide
- Lopinavir
- Lorlatinib
- Lovastatin
- Lumacaftor
- Lurasidone
- Maraviroc
- Mavacamten
- Methadone
- Midazolam
- Mitotane
- Modafinil
- Nafcillin
- Naloxegol
- Nefazodone
- Nelfinavir
- Netupitant
- Nilotinib
- Omaveloxolone
- Oxycodone
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Quetiapine
- Rifabutin
- Rifampin
- Ritonavir
- Roflumilast
- Saquinavir
- Sildenafil
- Simvastatin
- Sirolimus
- Sirolimus Protein-Bound
- St John's Wort
- Sufentanil
- Tacrolimus
- Telaprevir
- Telithromycin
- Temsirolimus
- Ticagrelor
- Tipranavir
- Tolvaptan
- Tramadol
- Triazolam
- Ubrogepant
- Vardenafil
- Venetoclax
- Venlafaxine
- Verapamil
- Voclosporin
- Voriconazole
- Zolpidem
Cautions
Patients should be monitored for signs of neurological adverse reactions, such as dizziness and gait disturbance. If severe neurological adverse reactions occur, dose modification or discontinuation may be necessary.
Tell your doctor if you have a history of liver problems before starting this drug.
Side Effects
The most common side effects include:
- Abdominal pain
- ALT/SGPT level raised
- Aspartate aminotransferase serum level above reference range
- Constipation
- Cough
- Diarrhea
- Dizziness
- Dyssomnia
- Fatigue
- Fever
- Fracture of bone
- Impaired cognition
- Mood disorder
- Musculoskeletal pain
- Nausea
- Vomiting
References
- Vitrakvi [package insert]. Stamford, CT: Loxo Oncology; November 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14206
-
Product Reviews
