What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vesanoid (Tretinoin)
Prescription Required
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Product Details
Description
Vesanoid, also known as Tretinoin, is a medication used to treat a type of cancer called acute promyelocytic leukemia (APL), which is a form of acute myeloid leukemia. Tretinoin helps APL cells mature properly, which can lead to improvements in the condition. It is classified as a chemotherapy drug, meaning it works by affecting how cells grow and develop. Vesanoid is taken in capsule form.
Fact Table
Formula
C20H28O2
License
US FDA
Bioavailability
50-60% (oral)
Legal status
Prescription only (Rx)
Chemical Name
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Elimination half-life
0.5–2 hours
Dosage (Strength)
10 mg capsules
Pregnancy
Contraindicated (Category X)
Brands
Vesanoid
Protein binding
>95%
PubChem CID
444795
MedlinePlus
a681043
ChEBI
15367
ATC code
L01XX14
DrugBank
DB00755
KEGG
D00084
Routes of administration
Oral, topical
Directions
When taking Vesanoid, the recommended dosage is 22.5 mg for every square meter of your body, taken orally twice daily until you reach complete remission or for a maximum of 90 days. Be sure to swallow the capsules whole with a full glass of water and take them at the same time each day. If you miss a dose, take it as soon as you remember, unless it's close to your next dose; in that case, skip the missed dose and continue your normal schedule.
Ingredients
Vesanoid contains the active ingredient Tretinoin.
Contraindications
Avoid taking or using this medication if you have a known hypersensitivity to Vesanoid, any of its components, or other retinoids.
Cautions
- Before beginning treatment with Vesanoid, it's important to discuss the following with your healthcare provider:
- Your current health conditions
- Any allergies you may have
- All medications you are currently using
- Whether you are pregnant or breastfeeding
- Vesanoid can cause significant harm to an unborn baby. Women who could become pregnant should use two effective forms of contraception during treatment and for one month after the last dose. Men should use effective contraception during and for one week after treatment.
- Differentiation syndrome is a life-threatening condition that has occurred in some patients, often within the first month of treatment. Symptoms include fever, weight gain, and respiratory distress. If you notice these symptoms, contact your healthcare provider immediately.
- If you have a high white blood cell count, Vesanoid might worsen this condition. Your doctor might give you chemotherapy alongside Vesanoid to manage this risk.
- Vesanoid can cause increased pressure in the brain, especially in children. Symptoms like headache, nausea, and vision problems need immediate medical evaluation.
- Since Vesanoid can increase cholesterol and triglycerides, regular monitoring of these levels is advised during treatment.
- Liver function should be tested before and during treatment as Vesanoid can cause liver enzyme elevations. If significant liver abnormalities are found, treatment may need to be adjusted.
- Vesanoid may increase the risk of blood clots, leading to stroke or heart attack. It's important to monitor for signs of such events, especially during the first month of treatment.
Side Effects
Vesanoid may lead to side effects like headaches, fever, bone pain, and malaise. Some people might also experience skin and mucous membrane dryness, respiratory issues like dyspnea, and various gastrointestinal discomforts including nausea and vomiting. These side effects are generally part of the body's response to the medication and can vary in intensity.
Serious side effects include differentiation syndrome, which involves fever and respiratory distress, and leukocytosis, where white blood cell counts are abnormally high. Vesanoid may also cause intracranial high blood pressure, significant liver issues (hepatotoxicity), and risky blood clots (thromboembolic events). If experiencing severe side effects like unmanageable pain, severe abdominal discomfort, or changes in mental status, it's important to seek immediate medical attention.
References
- Vesanoid (Tretinoin) Product Monograph. Montgomery, AL: H2-Pharma, LLC; 2023.
- Vesanoid (Tretinoin) Drug Label Information. Montgomery, AL: H2-Pharma, LLC; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11403
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