What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vectical Ointment (Calcitriol)
Prescription Required
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Product Details
Description
Vectical® Ointment contains calcitriol 3 mcg/g, a form of vitamin D3, formulated for topical application. It is indicated for the treatment of mild to moderate plaque psoriasis in adults and pediatric patients aged 2 years and older. Calcitriol functions by modulating skin cell production and differentiation, thereby reducing the plaque formation characteristic of psoriasis.
Fact Table
Formula
C27H44O3
License
US FDA
Bioavailability
Minimal systemic absorption (topical)
Legal status
Rx-only
Chemical Name
Calcitriol
Elimination half-life
5–8 hours (systemic, oral use)
Dosage (Strength)
3 mcg/g (0.0003%) ointment
Pregnancy
Category C – Use only if benefits justify risks
Brands
Vectical
Protein binding
>99.9%
PubChem CID
5280453
MedlinePlus
a682335
ChEBI
17823
ATC code
D05AX04
DrugBank
DB00136
KEGG
D01730
Routes of administration
Topical (skin)
Directions
Apply Vectical Ointment to the affected areas of the skin twice daily, in the morning and evening. For adults and children aged 7 years and older, the maximum weekly dose should not exceed 200 grams. For children aged 2 to 6 years, the maximum weekly dose should not exceed 100 grams. The ointment should not be applied to the eyes, lips, or facial skin. It is intended for topical use only and is not for oral, ophthalmic, or intravaginal use.
Ingredients
Active ingredient:
- Calcitriol 3 mcg/g
Inactive ingredients:
- Mineral oil
- dl-a-tocopherol
- White petrolatum
Contraindications
Vectical Ointment is contraindicated in patients with a known hypersensitivity to calcitriol or any component of the formulation. Additionally, it should not be used in patients with hypercalcemia or evidence of vitamin D toxicity.
Cautions
- Calcium Metabolism: Monitor serum calcium levels during treatment. If hypercalcemia occurs, discontinue use until levels normalize.
- Sun Exposure: Avoid excessive exposure to natural or artificial sunlight on treated areas.
- Pediatric Use: Safety and efficacy in children under 2 years of age have not been established.
- Pregnancy and Nursing: Use during pregnancy only if the potential benefit justifies the potential risk. Caution is advised when administered to nursing mothers.
Side Effects
Common side effects may include:
- Skin discomfort or irritation at the application site.
- Itching.
- Psoriasis worsening.
Serious side effects may include:
- Hypercalcemia (elevated calcium levels), which can manifest as weakness, fatigue, loss of appetite, or constipation.
- Kidney stones.
If any severe reactions occur, discontinue use and consult a healthcare provider promptly.
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IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12078
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