Vaseretic (Enalapril/HCTZ)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Vaseretic contains two medications–enalapril maleate and hydrochlorothiazide–to treat high blood pressure.
Enalapril maleate is classified as an angiotensin-converting enzyme (ACE) inhibitor; it prevents the production of angiotensin II, leading to blood vessel dilation and lower blood pressure. Hydrochlorothiazide is a thiazide diuretic, or fluid pill; it works by causing the kidneys to get rid of excess water and sodium, leading to a decrease in blood pressure.
Vaseretic is available in an oral tablet formulation that contains 10 mg of enalapril maleate and 25 mg hydrochlorothiazide.
Fact Table
Formula
C27H36ClN5O9S2
License
US DailyMed
Bioavailability
No effect
Legal status
Rx-Only
Chemical Name
Enalapril – Hydrochlorothiazide
Elimination half-life
5.6-14.8 hours
Dosage (Strength)
-
Pregnancy
Consult Doctor
Brands
Vaseretic
Protein binding
-
PubChem CID
9831269
MedlinePlus
a601047
ChEBI
4784
ATC code
C09BA02
DrugBank
DB00584
KEGG
D10277
Routes of administration
By mouth
Directions
Take Vaseretic exactly as prescribed by your doctor. Inform your doctor or pharmacist of any questions or concerns you have about your prescription.
Your dose will depend on your blood pressure goals and how well you tolerate the medication. The typical range is enalapril 10 mg to 40 mg and hydrochlorothiazide 12.5 mg to 50 mg by mouth every day.
Ingredients
Enalapril maleate and hydrochlorothiazide are the active ingredients contained in Vaseretic. Inactive ingredients include iron oxide, lactose, magnesium stearate, sodium bicarbonate, and starch.
Contraindications
Do not take Vaseretic if you are allergic to any of its ingredients.
Do not take Vaseretic with a neprilysin inhibitor (i.e., sacubitril). If you are switching to sacubitril/valsartan, wait at least 36 hours after your final dose of Vaseretic before you begin taking sacubitril/valsartan. If you are switching to Vaseretic, wait at least 36 hours after your final dose of sacubitril/valsartan before you begin taking Vaseretic.
Cautions
Vaseretic has the following Boxed Warning:
- Vaseretic should be stopped as soon as pregnancy is detected, as the medication can cause harm and death to an unborn baby.
- Before you start treatment with Vaseretic medication, inform your doctor of:
- All the medications you take, including over-the-counter medications, supplements, and vitamins
- Your allergies
- Your health conditions and past medical history
- Any planned surgeries and procedures
- Your pregnancy and breastfeeding status
- Vaseretic can cause low blood pressure.
- Anaphylactoid reactions can occur with Vaseretic treatment. These reactions can also occur in patients who take ACE inhibitors and undergo desensitizing treatment or are exposed to high-flux membranes.
- Angioedema, or swelling, can occur with ACE inhibitors. Seek medical care right away if you have swelling of the face, arms, legs, lips, tongue, and/or throat. Intestinal angioedema can also occur, so seek medical care right away if you develop stomach pain.
- Although rare, liver problems can occur with ACE inhibitors.
- Thiazide diuretics can cause a buildup of nitrogen waste products in patients who have kidney disease.
- Patients with liver problems should use thiazide diuretics with caution.
- Patients with bronchial asthma may develop sensitivity reactions.
- Lupus may worsen or develop.
- It is not recommended to take lithium with thiazide diuretics.
- Thiazide diuretics can cause vision problems such as glaucoma. Patients should seek emergency care right away if vision problems occur.
- Patients with certain heart problems should use Vaseretic with caution.
- Vaseretic can cause impaired kidney function.
- Vaseretic can cause elevated potassium levels in the blood.
- Vaseretic can cause a dry cough, which is associated with the enalapril component.
- Vaseretic can cause abnormal electrolyte levels.
Side Effects
Dizziness, headache, fatigue, and cough are common Vaseretic side effects; however, these are not the only side effects that can occur. Tell your doctor right away if you develop bothersome or persistent side effects.
You can buy Vaseretic online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
Reference:
Vaseretic. Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1886
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