What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Truqap (Capivasertib)
Prescription Required
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Product Details
Description
Truqap, also known as Capivasertib, is a treatment for certain types of breast cancer. It works by blocking specific enzymes that cancer cells need to grow and survive. Truqap is used for breast cancers that are hormone receptor-positive (HR-positive) or HER2-negative and have certain genetic changes in the PIK3CA, AKT1, or PTEN genes. Doctors often combine it with other cancer treatments for patients with advanced or metastatic cancer that hasn’t responded well to earlier treatments.
Fact Table
Formula
C26H37N5O2
License
EMA (conditional), FDA (under review)
Bioavailability
64% (oral)
Legal status
Prescription only (Rx)
Chemical Name
N-[4-[2-Amino-6-(cyclohexylmethoxy)pyrimidin-4-yl]-3-fluorophenyl]-6-(hydroxymethyl)-3-morpholinecarboxamide
Elimination half-life
6.5 hours
Dosage (Strength)
400 mg tablets
Pregnancy
Consult a doctor (Category Not Assigned)
Brands
Truqap
Protein binding
96%
PubChem CID
25142274
MedlinePlus
n/a
ChEBI
n/a
ATC code
L01XE59
DrugBank
DB12396
KEGG
D11080
Routes of administration
Oral
Directions
The recommended dosage of Truqap is 400 mg taken orally twice a day, either with or without food, for 4 consecutive days, followed by a 3-day break. It is important to maintain a consistent schedule by taking Truqap at the same times each day to ensure steady levels of the medication in the body.
Ingredients
Truqap contains the active ingredient Capivasertib.
Contraindications
Avoid taking Truqap if you have a known severe hypersensitivity to Capivasertib or any of the excipients in the formulation.
Cautions
- Before starting treatment with Truqap, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- Truqap can cause severe high blood sugar and ketoacidosis, particularly in patients with Type 1 diabetes or those needing insulin, who were not included in key studies. If you experience symptoms like excessive thirst or frequent urination, contact your healthcare provider right away.
- Before starting Truqap, your blood sugar and hemoglobin A1C levels should be checked. Continue to monitor your blood sugar regularly throughout treatment, especially if you have diabetes or risk factors for high blood sugar.
- Many patients on Truqap experience diarrhea, which can be severe. Stay hydrated and use anti-diarrheal medication at the first sign of diarrhea. Depending on the severity, your dose may need to be adjusted or treatment stopped.
- Truqap can cause serious skin reactions including erythema multiforme and DRESS. If you develop skin reactions, seek medical help. Treatment may involve corticosteroids and possibly stopping Truqap.
- Truqap can harm an unborn baby. Women who could become pregnant should use effective birth control during treatment and for one month after the last dose. Men with partners of reproductive potential should use effective contraception during treatment and for four months after the last dose.
Side Effects
Truqap side effects may include nausea and vomiting. Patients might experience general fatigue or develop mouth sores. It's also possible for some individuals to see changes in specific blood tests, which your healthcare provider will monitor regularly.
Truqap can lead to serious health issues, such as hyperglycemia, with symptoms including excessive thirst, dry mouth, increased urination, and confusion. Diarrhea is another severe side effect that may cause dehydration. Immediate medical attention is necessary for persistent diarrhea or skin reactions like rashes or blisters. Your healthcare provider may adjust your dosage or stop treatment based on the severity of these effects.
References
- Truqap (Capivasertib) Product Monograph. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2023.
- Truqap (Capivasertib) Drug Label Information. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14965
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