Trikafta (Ivacaftor/Elexacaftor/Tezacaftor)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Product Details
Description
Trikafta (elexacaftor/tezacaftor/ivacaftor and ivacaftor) is a combination medication that is prescribed to treat cystic fibrosis in patients who are least 2 years of age with at least one F508del mutation or another mutation in the CFTR gene that responds to treatment.
Trikafta comes in oral tablets of the following strengths:
- Fixed-dose combination containing elexacaftor 50 mg, tezacaftor 25 mg and
ivacaftor 37.5 mg co-packaged with ivacaftor 75 mg - Fixed-dose combination containing elexacaftor 100 mg, tezacaftor 50 mg,
and ivacaftor 75 mg co-packaged with ivacaftor 150 mg
Trikafta also comes in oral granules of the following strengths:
- Unit-dose packets of elexacaftor 100 mg, tezacaftor 50 mg and ivacaftor
75 mg co-packaged with unit-dose packets of ivacaftor 75 mg - Unit-dose packets of elexacaftor 80 mg, tezacaftor 40 mg and ivacaftor
60 mg co-packaged with unit-dose packets of ivacaftor 59.5 mg
Directions
Take Trikafta exactly as prescribed by your doctor. Carefully read the instructions for use that comes with your prescription. If you have any questions or concerns, talk to your doctor or pharmacist.
Your doctor will determine a dose and treatment duration that’s appropriate for you based on your age, weight, and medical problems. It is recommended to take Trikafta with food that contains fat; this helps it absorb better.
Ingredients
Elexacaftor/tezacaftor/ivacaftor are the active ingredients in Trikafta.
Inactive ingredients in elexacaftor, tezacaftor and ivacaftor fixed-dose combination tablets include croscarmellose sodium, hypromellose, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, hydroxypropyl cellulose, hypromellose, iron oxide red, iron oxide yellow, talc, and titanium dioxide.
Inactive ingredients in ivacaftor tablets ingredients include colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium lauryl sulfate, carnauba wax, FD&C Blue #2, PEG 3350, polyvinyl alcohol, talc, titanium dioxide, ammonium hydroxide, iron oxide black, propylene glycol, and shellac.
Inactive ingredients in the elexacaftor, tezacaftor and ivacaftor fixed-dose combination oral granules include colloidal silicon dioxide, croscarmellose sodium, hypromellose, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, mannitol, sodium lauryl sulfate, and sucralose.
Inactive ingredients in ivacaftor granules include colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, lactose monohydrate, magnesium stearate, mannitol, sodium lauryl sulfate, and sucralose.
Contraindications
There are no contraindications, or reasons why a person should not take Trikafta, per the most recent Prescribing Information. However, patients should consult their healthcare provider about whether Trikafta is right for them.
Cautions
- Before you begin treatment with Trikafta, talk to your doctor about:
- All the prescription medications you take, including prescription and over-the-counter medications
- Your allergies
- Your current health problems
- Your past medical history
- Your pregnancy or breastfeeding status
- Trikafta may cause the following:
- Elevated liver enzymes and liver injury. Trikafta should not be used in patients with advanced liver disease unless the benefits outweigh the risks.
- Allergic reactions including angioedema (swelling) and anaphylaxis.
- Cataracts
- Trikafta should not be used with CYP3A inducers such as rifampin and St. John’s wort. Trikafta may not work as well if they are taken together. Talk to your doctor if you are unsure whether you take CYP-3A inducers.
Side Effects
Headache, upper respiratory tract infection, abdominal pain, diarrhea, rash, increased liver enzymes, nasal congestion, blood creatine phosphokinase increased, runny nose, rhinitis, influenza, sinusitis, and increased blood bilirubin are some common Trikafta side effects. However, other side effects may also occur. Tell your doctor right away if you have side effects that bother you or won’t go away.
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Reference
Trikafta. Boston, MA: Vertex Pharmaceuticals Incorporated; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14393
- Fixed-dose combination containing elexacaftor 50 mg, tezacaftor 25 mg and
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