What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Treximet (Naproxen/Sumatriptan)
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Generic Equivalent - Treximet (Naproxen/Sumatriptan)
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Product Details
Description
Your doctor may prescribe Treximet to treat migraine headaches with or without aura. It contains two active ingredients: naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and sumatriptan, a selective serotonin receptor agonist.
Naproxen helps relieve pain and reduce inflammation, while sumatriptan constricts blood vessels in the brain and blocks the release of certain substances that cause migraine symptoms.
Fact Table
Formula
C32H40N3NaO9S
License
US FDA, EU EMA, US DailyMed
Bioavailability
15%(Sumatriptan), 95%(Naproxen)
Legal status
Rx-Only
Chemical Name
Naproxen/Sumatriptan
Elimination half-life
2.5 hours(Sumatriptan), 12–17 hours (Naproxen),
Dosage (Strength)
85mg/500mg (Generic)
Pregnancy
Not Recommended
Brands
Treximet
Protein binding
14–21%(Sumatriptan), 99%(Naproxen)
PubChem CID
23709079
MedlinePlus
a601116
ChEBI
10650
ATC code
None
DrugBank
DB00669
KEGG
D11577
Routes of administration
By mouth
Directions
The recommended dose is one tablet by mouth with water at the onset of a migraine headache. If the headache returns, a second tablet may be taken at least two hours after the first dose.
The maximum daily dose is two tablets in 24 hours. Do not exceed the recommended dosage or take this medication more often than prescribed.
Ingredients
The active ingredients are naproxen and sumatriptan.
Interactions
Common drug-drug interactions may include
- Abrocitinib
- Acemetacin
- Aminolevulinic Acid
- Antacids
- Apixaban
- Bemiparin
- Bromocriptine
- Caplacizumab
- CycloSPORINE
- Dabigatran Etexilate
- Diflunisal
- Edoxaban
- Enoxaparin
- Ergot Derivatives
- Heparin
- Ketorolac
- Lithium
- Loop Diuretics
- Macimorelin
- Methotrexate
- Mifamurtide
- Monoamine Oxidase Inhibitors
- Nonsteroidal Anti-Inflammatory Agents
- Phenylbutazone
- PRALAtrexate
- Rivaroxaban
- Salicylates
- Selective Serotonin Reuptake Inhibitors
- Serotonin 5-HT1D Receptor Agonists
- Sincalide
- Sucralfate
- Tenofovir Products
- Tenoxicam
- Urokinase
- Vitamin K Antagonists
Cautions
Tell your doctor if you have a history of severe liver or kidney disease, uncontrolled high blood pressure, or a history of heart disease or stroke.
It should not be used within 24 hours of taking another medication containing ergotamine or a triptan.
Tell your doctor if you have a history of seizures, stomach ulcers, or heart problems.
Side Effects
The most common side effects may include
- Acute myocardial infarction
- Cerebrovascular accident
- Chest discomfort
- Chest pain
- Coronary thrombosis
- Dizziness
- Drowsiness
- Dyspepsia
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hot flash
- Hypertonia
- Jaw pain
- Jaw pressure
- Jaw tightness
- Nausea
- Neck pain
- Neck pressure
- Neck tightness
- Pharyngeal edema
- Sore throat
- Xerostomia
References
Treximet [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2011.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13752
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