What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Treanda (Bendamustine)
Prescription Required
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Product Details
Description
Treanda, with the active ingredient bendamustine hydrochloride, is a prescription medication used for certain types of cancer, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL).
Bendamustine is an alkylating agent that interferes with the DNA in cancer cells, preventing their growth and leading to cell death. This mechanism helps slow the progression of the disease and can shrink tumors.
Fact Table
Formula
C16H21Cl2N3O2
License
US FDA
Bioavailability
100% (intravenous)
Legal status
Prescription only (?)
Chemical Name
4-[5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
Elimination half-life
40 minutes (active metabolite ~3 hours)
Dosage (Strength)
25 mg/m², 100 mg/m² powder for intravenous infusion
Pregnancy
Contraindicated
Brands
Treanda, Levact
Protein binding
95-96%
PubChem CID
65628
MedlinePlus
a608040
ChEBI
CHEBI:31179
ATC code
L01AA09
DrugBank
DB06769
KEGG
D07638
Routes of administration
Intravenous
Directions
Treanda is administered intravenously under the supervision of a healthcare professional. The dosage varies depending on the type of cancer being treated.
Ingredients
The active ingredient in Treanda is bendamustine.
Interactions
The most common drug-drug interactions may include:
- Adenovirus Vaccine, Live
- Amiodarone
- Bacillus of Calmette and Guerin Vaccine, Live
- Carbamazepine
- Cholera Vaccine, Live
- Ciprofloxacin
- Dengue Tetravalent Vaccine, Live
- Ebola Zaire Vaccine, Live
- Enoxacin
- Fluvoxamine
- Fosphenytoin
- Influenza Virus Vaccine, Live
- Interferon Alfa-2b
- Measles Virus Vaccine, Live
- Mexiletine
- Mumps Virus Vaccine, Live
- Obeticholic Acid
- Peginterferon Alfa-2a
- Phenytoin
- Poliovirus Vaccine, Live
- Rifampin
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Monkeypox Vaccine, Live Non-Replicating
- Smallpox Vaccine
- Typhoid Vaccine, Live
- Varicella Virus Vaccine, Live
- Vemurafenib
- Yellow Fever Vaccine
- Zoster Vaccine, Live
Cautions
Patients' absolute neutrophil count (ANC) and platelet counts should be closely monitored. Complications from myelosuppression can be fatal.
Patients should be monitored for fever and other signs of infection.
Treanda should be discontinued if severe skin reactions occur.
Treanda can cause fetal harm. Women should be advised to avoid becoming pregnant while receiving treatment.
Side Effects
The most common side effects may include:
- Acute myeloid leukemia
- Acute renal failure
- ALT/SGPT level raised
- Anaphylaxis
- Aspartate aminotransferase serum level above reference range
- Cough
- Constipation
- Decreased hemoglobin
- Decreased neutrophil count
- Decreased platelet count
- Dermatologic toxicity
- Diarrhea
- Dyspnea
- Fatigue
- Febrile neutropenia
- Fever
- Headache
- Hepatitis
- Hepatotoxicity
- Hypertensive crisis
- Hypersensitivity reaction
- Infusion reaction
- Infectious disease
- Injection site extravasation
- Leukopenia
- Loss of appetite
- Lymphocytopenia
- Myelodysplastic syndrome
- Myeloproliferative disorder
- Myelosuppression
- Nausea
- Pneumonia
- Pulmonary fibrosis
- Rash
- Sepsis
- Septic shock
- Skin cancer, Non-melanoma
- Squamous cell carcinoma of the bronchus
- Stevens-Johnson syndrome
- Stomatitis
- Thrombocytopenia
- Toxic epidermal necrolysis
- Tumor lysis syndrome
- Vomiting
- Weight decreased
References
Treanda [package insert]. Frazer, PA: Cephalon; October 2008.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14625
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