Description

Tracleer (Bosentan) works as an endothelin receptor antagonist (ERA), which means it blocks the effects of endothelin, a substance that constricts blood vessels and elevates blood pressure in the lungs. This medication treats pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that supply the lungs. Tracleer may help support patients' ability to exercise and prevent the condition from worsening over time. By doing so, Tracleer can help manage symptoms and improve the quality of life for individuals living with PAH.

Directions

Tracleer is taken orally, with an initial dosage typically starting at 62.5 mg twice daily for four weeks, before increasing to the maintenance dose of 125 mg twice daily. The actual dosage can vary depending on the patient’s age and weight. Patients may take Tracleer with or without food, but they must swallow the tablets whole—do not crush or split them. Always follow a healthcare provider’s instructions for taking Tracleer.

Ingredients

The active ingredient in Tracleer is Bosentan. It may also contain inactive ingredients, such as corn starch, ethylcellulose, glyceryl behenate, and hydroxypropylmethylcellulose.

Contraindications

If patients fall under any of the categories listed below, they should not take Tracleer:

• Pregnancy: Bosentan can cause harm to an unborn baby and must not be used during pregnancy
• Use with Cyclosporine A: Concurrent use can lead to increased levels of bosentan and potential toxicity
• Use with Glyburide: Can lead to an increased risk of liver injury and is not recommended
• Hypersensitivity to Bosentan: Patients with a known allergy to bosentan or any of its components should avoid this medication

Cautions

• It’s important to discuss the following with a healthcare provider before starting treatment:
• Any medications you take
• Other medical conditions you have
• Whether you have any allergies
• Whether you’re pregnant or breastfeeding
• Tracleer may cause fluid retention in some patients, which might require medical intervention. Monitoring for signs of fluid retention, such as swelling in the ankles or feet and sudden weight gain, is important.
• If you experience symptoms of pulmonary edema, such as shortness of breath or difficulty breathing, it could be a sign of pulmonary veno-occlusive disease (PVOD), a rare but serious lung disease. In such cases, discontinuation of Tracleer should be considered.
• Decreased sperm counts have been observed in patients taking Tracleer. This could be an important consideration for men looking to father children.
• Tracleer can lead to decreases in hemoglobin and hematocrit levels. It’s recommended to monitor hemoglobin levels after the first and third months of treatment, and then every three months thereafter.

Side Effects

Tracleer may cause side effects. The most common ones include respiratory tract infections, headaches, fainting, flushing, low blood pressure, sinusitis, joint pain, and irregular heartbeats. Serious side effects of Tracleer may include fluid retention, leading to ankle and leg swelling. Men may experience lower sperm counts, potentially affecting fertility. Anemia is another serious side effect, characterized by low red blood cell levels. Patients should inform their healthcare provider about any significant swelling, breathing difficulties, or concerns about fertility. Regular blood tests to monitor red blood cells are recommended during treatment. Prompt medical attention is recommended for severe symptoms.

References:

1. Tracleer (Bosentan) Product Monograph. San Francisco: Actelion Pharmaceuticals, Inc.; 2023.
2. Tracleer (Bosentan) Drug Label Information. San Francisco: Actelion Pharmaceuticals, Inc.; 2023.

About Dr. Gerardo Sison (Page Author)

Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....

Product Code : 9869