Tezspire (Tezepelumab-Ekko)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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Prescription Required

  • Product Details

    Description

    Tezspire (tezepelumab-ekko) is an injectable medication prescribed to treat severe asthma in adults and pediatric patients who are at least 12 years of age.

    Tezspire is available as a subcutaneous injection (underneath the skin):

    • 210 mg/1.91 mL(110 mg/mL) solution in a single-dose glass vial
    • 210 mg/1.91 mL(110 mg/mL) solution in a single-dose pre-filled syringe
    • 210 mg/1.91 mL(110 mg/mL) solution a single-dose pre-filled pen

    Tezspire Mechanism of Action: Tezspire is classified as a thymic stromal lymphopoietin (TSLP) blocker, meaning it blocks TSLP, which is part of the asthma inflammatory cascade. Blocking TSLP helps reduce airway inflammation, making breathing easier. However, the mechanism of action of Tezspire in asthma is not definitively known.

    Fact Table

    Formula

    C6484H10008N1732O2028S50

    License

    US FDA, EMA

    Bioavailability

    77% (subcutaneous)

    Legal status

    Prescription only

    Chemical Name

    Recombinant human IgG2 monoclonal antibody targeting thymic stromal lymphopoietin (TSLP)

    Elimination half-life

    26 days

    Dosage (Strength)

    210 mg/1.91 mL prefilled syringe

    Pregnancy

    Consult a doctor

    Brands

    Tezspire

    Protein binding

    Not significantly protein bound

    PubChem CID

    167728002

    MedlinePlus

    a621065

    ChEBI

    CHEBI:164371

    ATC code

    R03DX10

    DrugBank

    DB15297

    KEGG

    D11496

    Routes of administration

    Subcutaneous

    Directions

    Use Tezspire as directed by the prescribing doctor.

    Your doctor will decide on an appropriate treatment regimen for you.

    A healthcare professional will teach you or a caregiver how to properly store, prepare, administer, and discard Tezspire.

    Products, needles, and syringes should not be shared with other people.

    For further instructions for use, you may refer to the medication guide that comes with your Tezspire prescription.

    Contact your doctor or pharmacist if you have any questions or concerns.

    Ingredients

    The active ingredient in Tezspire is tezepelumab-ekko.

    Inactive ingredients include glacial acetic acid, L-proline, polysorbate 80, sodium hydroxide, and water for injection.

    Contraindications

    Patients with an allergy to tezepelumab-ekko or to any of the excipients in Tezspire should not use it.

    Cautions

    • Before you start treatment with Tezspire, talk to your doctor about:
      • All the prescription and over-the-counter medications you take
      • Your allergies
      • Your current health problems and past medical history
      • Your pregnancy or breastfeeding status
    • Tezspire contains the following warnings and precautions:
      • Hypersensitivity reactions, including anaphylaxis
      • Risk with abrupt reduction in corticosteroid dosage
      • Pre-existing parasitic (Helminth) infections should be treated before starting Tezspire
      • Live vaccines should be avoided

    Side Effects

    Pharyngitis, joint pain, and back pain are common Tezspire side effects; however, other side effects may also occur.

    Tell your doctor right away if you have side effects that bother you or won't go away.

    Searching for a competitive Tezspire cost? With a valid prescription, you can buy Tezspire right here!

    Reference

    Tezspire. Thousand Oaks, CA: Amgen Inc.; 2023.




    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13785

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