Description
Temodar is a prescription chemotherapy medication used in the treatment:
- Newly diagnosed glioblastoma multiforme (GBM) along with radiation
- Refractory anaplastic astrocytoma patients who have failed prior treatment
Temodar works by incorporating cancer cells' DNA and preventing their replication.
Fact Table |
Formula |
C6H6N6O2 |
License |
EU EMA, US FDA |
Bioavailability |
almost 100% |
Legal status |
Rx-only |
Chemical Name |
Temozolomide |
Elimination half-life |
1.8 hours |
Dosage (Strength) |
5mg, 20mg, 100mg, 180mg, 250mg |
Pregnancy |
Not Advised |
Brands |
Temodar, Temodal, Temcad |
Protein binding |
10–20% |
PubChem CID |
5394 |
MedlinePlus |
a601250 |
ChEBI |
72564 |
ATC code |
L01AX03 |
DrugBank |
DB00853 |
KEGG |
D06067
|
Routes of administration |
By mouth, intravenous |
Directions
Take Temodar exactly as prescribed by your doctor.
Ingredients
The active ingredient is temozolomide.
Interactions
There are many potential drug-drug interactions, including:
- Abrocitinib
- Baricitinib
- BCG Products
- Cladribine
- Coccidioides immitis Skin Test
- COVID-19 Vaccine
- Deferiprone
- Dengue Tetravalent Vaccine
- Denosumab
- Dipyrone
- Fexinidazole
- Influenza Virus Vaccines
- Leflunomide
- Lenograstim
- Lipegfilgrastim
- Live Vaccines
- Natalizumab
- Palifermin
- Pimecrolimus
- Poliovirus Vaccine
- Polymethylmethacrylate
- Rabies Vaccine
- Ropeginterferon Alfa-2b
- Rubella- or Varicella-Containing Live Vaccines
- Ruxolitinib
- Sipuleucel-T
- Tacrolimus
- Talimogene Laherparepvec
- Tertomotide
- Tofacitinib
- Typhoid Vaccine
- Upadacitinib
- Yellow Fever Vaccine
Cautions
Your oncology team should monitor the levels of your blood cells while taking this drug.
Do not take this drug if you are pregnant or intend to become pregnant.
Tell your doctor if you have a history of liver problems.
Side Effects
The most common adverse reactions include:
- Abdominal pain
- Abnormal gait
- Alopecia
- Amnesia
- Anaphylaxis
- Anemia
- Anorexia
- Anxiety
- Aplastic anemia
- Arthralgia
- Asthenia
- Ataxia
- Back pain
- Blurred vision
- Cholestasis
- Confusion
- Constipation
- Cough
- Decreased hemoglobin
- Decreased neutrophils
- Depression
- Diabetes Insipidus
- Diarrhea
- Diplopia
- Dizziness
- Drowsiness
- Dysgeusia
- Dysphagia
- Dyspnea
- Erythema multiforme
- Erythema of skin
- Fatigue
- Fever
- Headache
- Hematoma
- Hemiparesis
- Hepatitis
- Hepatotoxicity
- Hyperbilirubinemia
- Hypercorticoidism
- Hypersensitivity reaction
- Increased liver enzymes
- Infection
- Injection site reaction
- Insomnia
- Interstitial pneumonitis
- Irritation
- Leukopenia
- Lymphocytopenia
- Mastalgia
- Memory impairment
- Myalgia
- Myelodysplastic syndrome
- Nausea
- Pain
- Pancytopenia
- Paresis
- Paresthesia
- Peripheral edema
- Petechiae
- Pharyngitis
- Pneumonia
- Pneumonitis
- Pruritus
- Pruritus
- Pulmonary alveolitis
- Pulmonary fibrosis
- Secondary acute myelocytic leukemia
- Seizure
- Sinusitis
- Skin rash
- Stevens-Johnson Syndrome
- Stomatitis
- Swelling
- Thrombocytopenia
- Toxic epidermal necrolysis
- Upper respiratory tract infection
- Urinary frequency
- Urinary incontinence
- Urinary tract infection
- Viral infection
- Visual disturbance
- Vomiting
- Warmth
- Weight gain
- Xeroderma
References
Temodar [package insert]. Whitehouse Station, NJ: Merck & Co., Inc.; 2016.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 10054