What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tagrisso (Osimertinib)
Prescription Required
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Product Details
Description
Tagrisso (osimertinib) is prescribed to treat adults with non-small cell lung cancer (NSCLC) that contains certain abnormal epidermal growth factor receptor (EGFR) genes.
Tagrisso is available in 40 mg and 80 mg oral tablets.
Fact Table
Formula
C28H33N7O2
License
US FDA, EMA
Bioavailability
~70%
Legal status
Prescription only (Rx)
Chemical Name
(N-[2-[2-Dimethylaminoethyl(methyl)amino]-4-methoxy-5-(3-(prop-2-en-1-yloxy)anilino)pyrimidin-5-yl]-4-(methylsulfonyl)phenyl]acetamide)
Elimination half-life
48 hours
Dosage (Strength)
40 mg, 80 mg tablets
Pregnancy
Contraindicated
Brands
Tagrisso
Protein binding
95%
PubChem CID
71496458
MedlinePlus
a615041
ChEBI
CHEBI:90908
ATC code
L01EB04
DrugBank
DB09330
KEGG
D10711
Routes of administration
Oral
Directions
Take Tagrisso for lung cancer exactly as prescribed by your doctor. Your doctor will determine an appropriate dose and treatment duration for you.
The recommended dose is 80 mg by mouth one time a day; take with or without food.
For further instructions for use, refer to the medication guide that accompanies your prescription.
Keep Tagrisso stored at 25°C (77°F) and out of children’s reach.
If you have any questions or concerns about Tagrisso, talk to your doctor or pharmacist.
Ingredients
The active ingredient in Tagrisso is osimertinib.
Inactive ingredients include mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, sodium stearyl fumarate, polyvinyl alcohol, titanium dioxide, macrogol 3350, talc, ferric oxide yellow, ferric oxide red, and ferric oxide black.
Contraindications
There are no contraindications to Tagrisso per the most recent Prescribing Information. Ask your doctor whether Tagrisso is an appropriate treatment for you.
Cautions
- Before you begin taking Tagrisso, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Tagrisso is associated with the following warnings and precautions:
- Interstitial lung disease and pneumonitis
- Prolongation of the QT interval, a type of abnormal heart rhythm
- Cardiomyopathy
- Keratitis, which is inflammation of the cornea of the eye
- Severe skin disorders, such as Erythema Multiforme Major, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis
- Cutaneous vasculitis
- Aplastic anemia
- Harm to an unborn baby. Females of childbearing potential are recommended to use effective contraceptive methods while receiving Tagrisso and for 6 weeks after taking the last dose. Males with female partners who are of childbearing potential are recommended to use effective contraceptive methods while receiving Tagrisso and for 4 months after taking the last dose.
Side Effects
Abnormal blood cell counts, anemia, rash, diarrhea, musculoskeletal pain, nail toxicity, fatigue, mouth swelling/sores, and dry skin are common Tagrisso side effects; however, other side effects can also occur. Immediately talk to your doctor about any side effects that bother you or won’t go away.
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Reference
Tagrisso. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13863
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