What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tabrecta (Capmatinib)
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Product Details
Description
Tabrecta (Capmatinib) is a kinase inhibitor, a type of medication used to treat adult patients with metastatic non-small cell lung cancer (NSCLC), a form of lung cancer that has spread beyond the lungs. This drug targets and blocks the activity of a particular protein associated with the MET gene in cancer cells, which can cause these cells to grow and spread. Capmatinib helps by interrupting these processes, which may help control the progression of the disease. It is indicated for patients whose tumors show a mutation leading to mesenchymal-epithelial transition (MET) exon 14 skipping, which is a specific genetic change.
Directions
Tabrecta is an oral tablet that should be used as directed by a health care provider. The standard dosage is 400 mg twice daily with or without meals. Swallow the tablets whole without crushing or splitting them. Consult a healthcare provider for regular assessments and to manage any potential problems with treatment.
Ingredients
The active ingredient in Tabrecta is Capmatinib. Tabrecta tablets may also contain inactive ingredients to help maintain the stability of the drug and improve its absorption into the body. These ingredients may include colloidal silicon dioxide, magnesium stearate, and mannitol, among others.
Contraindications
There are no known or reported contraindications mentioned on the drug label.
Cautions
- Before starting Tabrecta, inform your doctor:
- If you are currently taking any other medications, including over-the-counter drugs, herbal supplements, or vitamins.
- Of any pre-existing conditions you might have, particularly those that affect the liver, lungs, or pancreas.
- Whether you are pregnant or intending to conceive, given the potential risks to the developing fetus.
- If you are breastfeeding because Tabrecta may be transferred through breast milk.
- Watch for signs of interstitial lung disease (ILD) or pneumonitis. Symptoms like new or worsening lung problems should be monitored. If ILD/pneumonitis is diagnosed, Tabrecta should be permanently discontinued.
- Tabrecta may cause liver toxicity. Your healthcare provider may monitor your liver function tests regularly. Depending on the severity of liver issues, treatment with Tabrecta may need to be withheld or adjusted.
- Pancreatic toxicity is another potential risk. Your healthcare provider may check your amylase and lipase levels to monitor your pancreatic function. Again, based on the severity, Tabrecta treatment might be changed or stopped.
- If you experience hypersensitivity reactions, Tabrecta may need to be temporarily or permanently discontinued, depending on the severity of the reaction.
- There is a risk of photosensitivity reactions with Tabrecta. It’s recommended to limit direct exposure to ultraviolet light, such as sunlight, to reduce this risk.
- Tabrecta may cause harm to an embryo or fetus. If you are pregnant or planning to become pregnant, discuss the potential risks with your healthcare provider. Use effective contraception during treatment with Tabrecta to avoid pregnancy.
Side Effects
Common Tabrecta side effects include a decreased appetite, cough, and bloating or swelling of the face, arms, hands, lower legs, or feet. Individuals might also experience difficulty breathing, headache, and muscle or bone pain. Nausea and vomiting are additional side effects that people might find bothersome.
The medication has the potential to cause more serious side effects that may require immediate medical attention. These include lung or breathing problems, marked by new or worsening symptoms such as a severe cough or trouble breathing, and liver problems noticeable by yellowing of the skin or eyes, among other symptoms. Other serious side effects might involve problems with the pancreas and severe skin reactions such as rashes. If you notice severe symptoms, contact a healthcare provider right away.
References:
- Tabrecta (Capmatinib) Product Monograph. East Hanover, NJ: Novartis Pharmaceuticals; 2023.
- Tabrecta (Capmatinib) Drug Label Information. East Hanover, NJ: Novartis Pharmaceuticals; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14426
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