Somavert (Pegvisomant)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Somavert (pegvisomant), an injectable medication, is used to treat patients with acromegaly who did not respond well to surgery or radiation therapy or other therapies that were not appropriate. The goal of treatment with Somavert is to help insulin-like growth factor-1 levels in the blood achieve normal levels.
Somavert is available in single-dose vials containing 10 mg, 15 mg, 20 mg, 25 mg, or 30 mg lyophilized powder for reconstitution.
Fact Table
Formula
C990H1532N262O300S7
License
US FDA, EMA
Bioavailability
57% (Subcutaneous administration)
Legal status
Prescription only (Rx)
Chemical Name
Pegvisomant
Elimination half-life
6 days
Dosage (Strength)
10 mg, 15 mg, 20 mg, 25 mg, 30 mg per vial
Pregnancy
Consult a doctor
Brands
Somavert
Protein binding
Not reported
PubChem CID
6918283
MedlinePlus
a604016
ChEBI
CHEBI:72276
ATC code
H01AX01
DrugBank
DB00082
KEGG
D05276
Routes of administration
Subcutaneous
Directions
Your doctor will determine an appropriate treatment regimen for you. A healthcare professional will instruct you or your caregiver on the proper storage, preparation, administration, and disposal of Somavert. The medication should be injected subcutaneously (underneath the skin) of the upper arm, thigh, abdomen, or buttocks; the injection site should be different with each injection.
Before reconstitution, Somavert should be stored in the refrigerator between 2°C to 8°C (36°F to 46°F); avoid freezing. Keep the medication away from children.
Never reuse or share needles and syringes with others.
Talk to your doctor or pharmacist about any questions or concerns you may have.
Ingredients
The active ingredient in Somavert is pegvisomant, including polyethylene glycol.
Inactive ingredients include glycine, mannitol, sodium dihydrogen phosphate monohydrate, and sodium phosphate dibasic anhydrous.
Contraindications
There are no contraindications to Somavert per the most recent Prescribing Information.
Cautions
- Before you start treatment with Somavert, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Somavert is associated with the following warnings and precautions:
- Low blood glucose levels
- Liver problems
- Systemic hypersensitivity
- Improved fertility, which may result in unintended pregnancy
Side Effects
Infection, pain, nausea, diarrhea, abnormal liver tests, flu syndrome, and injection site reactions are common side effects associated with Somavert; however, other side effects may also occur. Immediately inform your doctor of any side effects that bother you or won’t go away.
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Reference
Somavert. New York, NY: Pharmacia & Upjohn Company LLC; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14561
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