Signifor Lar (Pasireotide)
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Product Details
Description
Signifor LAR (Pasireotide) is a prescription medicine belonging to a class of drugs known as somatostatin analogs. It primarily assists in treating adults with acromegaly, a condition typically occurring when the pituitary gland produces an excess of growth hormone. It is also approved for Cushing’s disease. Pasireotide functions by mimicking the effects of the natural hormone somatostatin, which blocks the release of several hormones including growth hormone. Administered as an injectable suspension, Signifor LAR offers a therapeutic option for patients where surgery has not been effective or is not a viable option.
Directions
Signifor LAR is an injectable suspension specifically designed for intramuscular use. Healthcare providers administer Signifor LAR in a clinical setting. For treating acromegaly, the typical initial dose is 40 mg once every four weeks. In the case of Cushing's disease, patients may start with a lower dose of 10 mg, also administered intramuscularly every four weeks.
It's important to adhere to the scheduled dosing regimen and monitor any adverse effects or necessary adjustments in dosing with your healthcare professional. As with any medication, follow your doctor's instructions closely, and do not alter the dose unless directed by your healthcare provider.
Ingredients
Pasireotide is the active ingredient in Signifor LAR injections.
Contraindications
There are no contraindications currently listed on the drug label.
Cautions
- Before initiating treatment with Signifor Lar, make sure to inform your healthcare provider about the following:
- Any health conditions you have
- Any allergies
- The complete list of medications you are currently taking
- Your pregnancy or breastfeeding status
- Signifor LAR can significantly raise your blood sugar levels, potentially leading to diabetes or even ketoacidosis, a severe condition resulting from untreated high blood sugar. You should regularly check your blood sugar levels, especially after starting treatment, changing your dose, or stopping the medication. If you notice symptoms like increased thirst, frequent urination, or extreme tiredness, contact your healthcare provider immediately.
- This medication may cause a decrease in heart rate or prolong the QT interval, a specific measure on an ECG that can affect heart rhythm. Prior to starting treatment and at intervals during your treatment, you'll need an ECG and possibly blood tests to monitor your electrolytes, which help regulate heart function.
- Signifor LAR can affect liver enzymes, indicating changes in liver health. Your doctor will perform tests to check your liver function before you start treatment and continue to monitor it during treatment.
- There is a risk of developing gallstones when taking Signifor LAR. If you develop symptoms such as intense abdominal pain, fever, or yellowing of the skin or eyes, it’s crucial to seek medical attention promptly as these could indicate complications from gallstones.
- Since Signifor LAR impacts hormone levels produced by the pituitary gland, regular monitoring of these hormones is essential. Any significant changes might require additional treatment.
Side Effects
Common side effects of Signifor LAR include diarrhea, headaches, stomach pain, hair loss, nasal congestion, sore throat, nausea, increased levels of certain enzymes, tiredness, bloating, low blood sugar, high blood pressure, swelling in limbs, back pain, and decreased appetite. These effects are generally manageable but can affect daily activities.
Signifor LAR can lead to significant health issues like high blood sugar (hyperglycemia), diabetes, and ketoacidosis, a condition needing prompt treatment highlighted by symptoms such as increased thirst, frequent urination, nausea, and confusion. It can also cause a slow heart rate (bradycardia) and changes in the heart's electrical activity, necessitating close monitoring for those with heart conditions. Gallstones and related complications may occur, requiring ultrasound monitoring for symptoms like severe abdominal pain and jaundice. Additionally, Signifor LAR may reduce pituitary hormone levels, with symptoms including nausea, vomiting, and dizziness. Regular medical follow-ups are crucial to monitor and manage these potential risks.
References:
- Signifor Lar (Pasireotide) Product Monograph. Lebanon, NJ: Recordati Rare Diseases Inc.; 2020.
- Signifor Lar (Pasireotide) Drug Label Information. Lebanon, NJ: Recordati Rare Diseases Inc.; 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14916
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