What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Rozlytrek (Entrectinib)
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Product Details
Description
Rozlytrek, or Entrectinib, is a medicine used to treat specific types of cancer, including ROS1-positive non-small cell lung cancer and solid tumors with NTRK gene fusions. It works by blocking certain proteins that help tumors grow. Rozlytrek comes in the form of capsules, which patients take by mouth. By targeting these specific gene changes, it helps slow down or stop the growth of cancer cells in affected patients.
Directions
Rozlytrek is typically taken once daily, either as capsules or oral pellets. It’s important to swallow the capsules whole; do not crush, chew, or dissolve them. For oral pellets, follow the specific mixing instructions provided by your doctor. Adults usually start with a standard dosage of 600 mg per day. Children’s dosage depends on their size and weight.
Store Rozlytrek at room temperature. Keep it in its original container to maintain its effectiveness and protect it from moisture. Make sure to keep this medication out of the reach of children. Always adhere to your healthcare provider's instructions regarding dosage and any specific advice they give for your condition.
Ingredients
The active ingredient in Rozlytrek is Entrectinib.
Contraindications
There are no specific contraindications listed on the drug label. However, individuals should avoid taking or using Rozlytrek if they have an allergy to Entrectinib or any other ingredient in the formulation.
Cautions
- Before beginning treatment with Rozlytrek, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- Rozlytrek may lead to congestive heart failure, especially if you have a history of heart problems. Watch for signs like shortness of breath or swelling in your legs and contact your doctor immediately if you notice them.
- Rozlytrek may affect your thinking and mood. You might experience confusion, memory issues, anxiety, or depression. If you notice any changes in your mental state, talk to your healthcare provider right away.
- Taking Rozlytrek can increase your risk of bone fractures, particularly in younger individuals. Be careful to avoid falls and injuries, and inform your doctor if you experience any bone pain or fractures.
- Rozlytrek can affect your liver. Your doctor will monitor your liver enzymes during treatment. If you feel unusually tired, nauseous, or notice yellowing of your skin or eyes, contact your doctor immediately.
- Rozlytrek may raise your uric acid levels, which can lead to gout. Watch for symptoms like sudden joint pain, especially in the big toe, and inform your doctor if they occur.
- Rozlytrek can affect your heart's rhythm by prolonging the QT interval. If you have a history of heart rhythm issues or are taking other medications that affect your heart, discuss this with your doctor before starting Rozlytrek.
- Rozlytrek might cause changes in your vision, such as blurred vision or sensitivity to light. If you experience any vision changes, stop taking Rozlytrek and seek medical advice immediately.
- Rozlytrek can harm an unborn baby. If you are pregnant or planning to become pregnant, use effective contraception during treatment and for five weeks after the last dose. Men with female partners who can become pregnant should use contraception during treatment and for three months after the last dose.
Side Effects
The most common side effects of Rozlytrek include tiredness, nausea, and weight gain. You may also experience constipation, muscle and joint pain, dizziness, and changes in taste or vision. Some people report confusion, memory problems, hallucinations, or other changes in mental status. Other side effects can include cough, shortness of breath, vomiting, and swelling.
Rozlytrek can cause serious side effects like congestive heart failure, leading to symptoms such as shortness of breath, swelling in the legs, and fatigue. It may also affect your central nervous system, causing dizziness, mood changes, or confusion. Bone fractures and liver problems have also been reported. If you notice signs of high uric acid levels, such as joint pain or pink urine, or if you experience irregular heartbeats or vision changes, contact your healthcare provider immediately.
References
- Rozlytrek (Entrectinib) Product Monograph. South San Francisco, CA: Genentech USA, Inc.; 2024.
- Rozlytrek (Entrectinib) Drug Label Information. South San Francisco, CA: Genentech USA, Inc.; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14620
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