What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Rinvoq ER (Upadacitinib)
Prescription Required
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Product Details
Description
Your doctor may prescribe Rinvoq for severe active rheumatoid arthritis if you have already tried and failed other medications like methotrexate. Rinvoq is sometimes given along with methotrexate and other medications for rheumatoid arthritis.
Rheumatoid arthritis is an autoimmune disorder where the immune system attacks the joints, including the hands, knees, and feet. Symptoms include pain, stiffness, tenderness, and swelling in the joints.
Rinvoq works by decreasing the activity of the immune system. By lowering the activity of the immune system, Rinvoq decreases symptoms of rheumatoid arthritis.
Fact Table
Formula
C17H19F3N6O
License
US FDA, EU EMA
Bioavailability
80%
Legal status
Rx-only
Chemical Name
Upadacitinib
Elimination half-life
9–14 hours
Dosage (Strength)
15mg
Pregnancy
Not Recommended
Brands
Rinvoq ER
Protein binding
52%
PubChem CID
58557659
MedlinePlus
a619051
ChEBI
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ATC code
L04AA44
DrugBank
DB15091
KEGG
D10994
Routes of administration
By mouth
Directions
The usual Rinvoq dosing is 15 mg by mouth once daily.
Ingredients
The active ingredient in Rinvoq is upadacitinib.
Interactions
Tell your doctor or pharmacist if you are taking any of the following before starting Rinvoq:
- Apalutamide
- Atazanavir
- Carbamazepine
- Ceritinib
- Clarithromycin
- Darunavir
- Enzalutamide
- Fosphenytoin
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lonafarnib
- Lopinavir
- Lumacaftor
- Lumacaftor-ivacaftor
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Ombitasvir-paritaprevir-ritonavir
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Rifampin (rifampicin)
- Saquinavir
- Telithromycin
- Tucatinib
- Voriconazole
Cautions
Rinvoq should not be used with biologic DMARDs or potent immunosuppressants like cyclosporine and azathioprine.
Some patients are at higher risk of developing serious infections while taking Rinvoq.
Tell your doctor if you have a history of latent tuberculosis infection.
Drugs like Rinvoq can increase the likelihood of blood clots and certain cancers like lymphoma.
Do not receive live vaccinations while taking Rinvoq.
Side Effects
Some of the common adverse reactions to Rinvoq may include:
- Cough
- Fever
- Increased liver enzymes
- Nausea
- Pyrexia
- Upper respiratory tract infection
References
Rinvoq [package insert]. Whippany, NJ: Abbvie; 2019.
Frequently Asked Questions about Rinvoq
What is Rinvoq?
Rinvoq is a prescription medication that contains the active ingredient upadacitinib. It belongs to a class of drugs known as Janus kinase (JAK) inhibitors and is used to treat certain autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
How does Rinvoq work?
Rinvoq works by inhibiting specific enzymes called Janus kinases (JAKs) that play a role in the inflammatory process. By blocking these enzymes, Rinvoq helps reduce inflammation and relieve the symptoms associated with autoimmune diseases.
What conditions are treated with Rinvoq?
Rinvoq is primarily used to treat adults with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. It may also be prescribed for other autoimmune conditions as determined by your healthcare provider.
Is Rinvoq safe for everyone?
No, Rinvoq may not be safe for everyone. It should not be used in individuals with certain medical conditions, such as severe infections, certain gastrointestinal disorders, or a history of certain cancers. Your healthcare provider will assess whether Rinvoq is suitable for you.
What are the common side effects of Rinvoq?
Common side effects of Rinvoq may include upper respiratory tract infections, headache, high blood pressure, and changes in certain blood test results. It's important to discuss potential side effects with your healthcare provider.
Can Rinvoq be taken with other medications?
Rinvoq may interact with other medications, including certain immunosuppressive drugs and live vaccines. It's essential to inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.
Is Rinvoq safe during pregnancy and breastfeeding?
Rinvoq may pose risks to a developing fetus, and its use during pregnancy should be discussed with a healthcare provider. It is not recommended during breastfeeding, and a decision should be made to either discontinue breastfeeding or discontinue Rinvoq, depending on the individual's condition and treatment needs.
How is Rinvoq administered?
Rinvoq is available in tablet form and is usually taken once a day with or without food, as directed by your healthcare provider. The dosage may vary depending on the condition being treated.
Is Rinvoq an addictive medication?
Rinvoq is not considered an addictive medication. It is prescribed by healthcare providers to manage autoimmune conditions and should be taken as directed.
What should I do if I miss a dose of Rinvoq?
If you miss a dose of Rinvoq, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13282
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