What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Reyataz (Atazanavir)
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Product Details
Description
Reyataz (atazanavir) is a medication used with other antiretroviral medications to treat HIV-1 infection in adults and pediatric patients who are at least 3 months old and weigh 5 kg or more.
Fact Table
Formula
C38H52N6O7
License
EU EMA, US DailyMed
Bioavailability
60-68%
Legal status
Rx-Only
Chemical Name
Atazanavir
Elimination half-life
6.5 hours
Dosage (Strength)
150mg, 200mg, 300mg
Pregnancy
Consult doctor
Brands
Reyataz
Protein binding
86%
PubChem CID
148192
MedlinePlus
a603019
ChEBI
37924
ATC code
J05AE08
DrugBank
DB01072
KEGG
D01276
Routes of administration
By mouth
Directions
Reyataz is available in oral capsules and an oral powder.
Follow the instructions that are on your prescription's label and read the package insert. If you have any questions or concerns, reach out to your doctor or pharmacist.
Recommended Dosing
Treatment-naive adults:
- Take Reyataz 300 mg by mouth with ritonavir 100 mg by mouth one time a day. Take with food.
- For patients who cannot tolerate ritonavir, they are recommended to take Reyataz 400 mg by mouth one time a day. Take with food.
- If taking efavirenz, take Reyataz 400 mg by mouth with ritonavir 100 mg by mouth one time a day.
Treatment-experienced adults:
- Take Reyataz 300 mg by mouth with ritonavir 100 mg by mouth one time a day. Take with food.
- If taking with H2RA and tenofovir DF, take Reyataz 400 mg by mouth with ritonavir 100 mg by mouth one time a day.
Pediatric patients:
- Dosing with the Reyataz oral capsules is determined by body weight. The dose should not be more than the adult dose. Take with food.
Reyataz oral powder:
- Administer with ritonavir and with food. Avoid use in pediatric patients who weigh less than 5 kg.
Pregnancy:
- Take Reyataz 300 mg by mouth with ritonavir 100 mg by mouth one time a day. Take with food.
Dose adjustments:
- The dose of Reyataz may need to be adjusted based on other medications, kidney function, and liver function.
Ingredients
Atazanavir sulfate, an HIV-1 protease inhibitor, is the active ingredient in Reyataz capsules and oral powder.
The inactive ingredients contained in Reyataz capsules include crospovidone, lactose monohydrate, and magnesium stearate. The inactive ingredients that make up the shells of the capsules include gelatin, FD and C Blue No. 2, titanium dioxide, black iron oxide, red iron oxide, and yellow iron oxide. The ink that is printed on the capsules contain shellac, titanium dioxide, FD&C Blue No. 2, isopropyl alcohol, ammonium hydroxide, propylene glycol, n-butyl alcohol, simethicone, and dehydrated alcohol.
The inactive ingredients contained in Reyataz oral powder include aspartame, sucrose, and orange-vanilla flavor.
Contraindications
Do not take Reyataz if you are allergic to atazanavir or any of the other ingredients contained in Reyataz.
Do not take Reyataz with alfuzosin, amiodarone (if Reyataz is given with ritonavir), quinidine (if Reyataz is given with ritonavir), triazolam, oral midazolam, ergo derivatives, rifampin, irinotecan, lurasidone (if Reyataz is given with ritonavir), lovastatin, simvastatin, lomitapide, indinavir, cisapride, pimozide, St. John's wort, nevirapine, elbasvir/grazoprevir, glecaprevir/pibrentasvir, and sildenafil (when dosed as Revatio). If you are unsure whether or not you take these medications, ask your doctor.
Cautions
- Before starting treatment with Reyataz, be sure to discuss the following with your doctor:
- Your allergies
- Your medical history
- Your medications
- Your pregnancy status
- Your breastfeeding status
- Reyataz can cause problems with cardiac conduction and prolong the PR interval. Talk to your doctor about your risks.
- Reyataz can cause serious skin reactions. Contact your doctor right away if you develop a rash or other skin reactions.
- Reyataz can cause elevations in indirect bilirubin levels.
- Phenylalanine is found in Reyataz powder which can harm patients who have phenylketonuria.
- Reyataz can cause liver injury or damage. You are at risk if you have hepatitis B or C.
- Reyataz can cause kidney problems.
- Reyataz can cause kidney stones and gallstones.
- Reyataz can cause or worsen diabetes mellitus and high blood sugar levels, immune reconstitution syndrome, and body fat redistribution or accumulation.
- Reyataz can cause bleeding in patients who have hemophilia type A and B.
Side Effects
Nausea, yellowing of the skin and eyes, rash, headache, stomach pain, vomiting, trouble sleeping, peripheral neurological problems, dizziness, muscle pain, diarrhea, depression, and fever can occur with the use of Reyataz. However, these are not all the possible side effects that can occur with the use of Reyataz. Call your doctor right away if you have side effects that are bothersome or persistent.
Reference:
Reyataz (atazanavir). Princeton NJ: Bristol-Myers Squibb Company; 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11329
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