Description
Retin-A Cream (Tretinoin) is a prescription medication that is applied to the skin and can treat acne vulgaris. Retin-A may also be used “off-label” for the palliation of fine wrinkles, treatment of roughness of facial skin, and to help with mottled hyperpigmentation.
Tretinoin is a naturally occurring derivative of Vitamin A. When applied to the skin, it changes the way epithelial cells grow and differentiate. In people with acne, it decreases microcomedo formation and decreases the cohesiveness of follicular epithelial cells.
Directions
Apply a thin layer to the affected acne lesions once daily before bedtime or in the evening.
Wash hands with soap and water after applying. Do not get the medication in the mouth or eyes. If contact with the mouth or eyes does occur, gently rinse with water.
Ingredients
The active ingredient in Retin-A cream is isotretinoin.
Retin-A cream comes in the following strengths:
- Retin-A Cream 0.025%
- Retin-A Cream 0.05%
- Retin-A Cream 0.01%
Fact Table |
Formula |
C20H28O2 |
License |
US FDA |
Bioavailability |
Minimally absorbed following topical application |
Legal status |
US: RX Only |
Chemical Name |
Tretinoin |
Elimination half-life |
0.5-2 hours |
Dosage (Strength) |
0.01%, 0.025%, 0.05%, 0.1% |
Pregnancy |
Consult a doctor |
Brands |
Retin A Cream |
Protein binding |
Greater than 95% |
PubChem CID |
445354 |
MedlinePlus |
a608032 |
ChEBI |
15367 |
ATC code |
L01XF01 |
DrugBank |
DB00755 |
KEGG |
D00094 |
Routes of administration |
Topical |
Cautions
Retin-A Cream may cause increased sensitivity to sunlight and ultraviolet (UV) light. Avoid excessive exposure to sun or sunlamps while using Retin-A cream. Use a sunscreen (SPF 15) daily as well as other protective measures like clothing when exposed to sunlight. Tell your doctor if you have a family history of skin cancer.
Retin-A Cream may increase sensitivity to other weather conditions like wind and cold.
Use other topical products with caution while using Retin-A, as multiple topical medications may increase the chances of redness and irritation.
Tell your doctor if you have a history of skin conditions like eczema or psoriasis.
Do not use on open sores or wounds.
Side Effects
Some of the most common adverse effects of Retin-A cream may include:
- Application site irritation
- Burning
- Desquamation
- Dryness
- Erythema
- Exfoliation
- Hypopigmentation
- Pruritus
- Stinging of the skin
Buying Retin-A Cream online can be faster, easier, and more convenient than going to the local pharmacy.
References
- Retin-A [package insert]. Skillman, New Jersey: Ortho Dermatological (n.d.).
- Acne Vulgaris, Merck Manuals, December 2018. Retrieved May 2020.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1775