What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Reglan (Metoclopramide)
Also Known as Maxolon
Prescription Required
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Product Details
Description
Reglan (metoclopramide) is a prescription medication used to treat and prevent post-op and chemotherapy-induced nausea and vomiting. It is also used to facilitate intestinal intubation and as a diagnostic aid during gastrointestinal radiography. In addition, it is used to treat symptomatic gastroesophageal reflux disease (GERD), diabetic and postsurgical gastroparesis, migraine, persistent hiccups, lactation induction, radiation sensitization, pregnancy-induced nausea and vomiting, facilitation of gastric emptying in babies with feeding intolerance, Tourette’s syndrome or chronic tic disorders, and cyclic vomiting syndrome.
Reglan comes in various dosage forms and strengths, including:
- 5 mg/mL intramuscular injection
- 5 mg/mL intravenous injection
- 5 mg and 10 mg oral tablets
- 5 mg and 10 mg orally disintegrating tablets
Fact Table
Formula
C14H22ClN3O2
License
US DailyMed, US FDA
Bioavailability
80 ± 15% (by mouth)
Legal status
Rx-only
Chemical Name
Metoclopramide
Elimination half-life
5–6 hours
Dosage (Strength)
5mg, 10mg
Pregnancy
Consult Doctor
Brands
Reglan is one of the brand names for metoclopramide. It may also be sold under other brand names.
Protein binding
Metoclopramide has a moderate protein binding of approximately 30%
PubChem CID
4168
MedlinePlus
a684035
ChEBI
107736
ATC code
A03FA01
DrugBank
DB01233
KEGG
D00726
Routes of administration
By Mouth
Directions
Use Reglan as instructed by your doctor. If you have any questions or concerns, talk to your doctor or pharmacist.
The recommended dose and dosage form of Reglan depends on the condition being treated. Your doctor will help you determine the dosage form and dose of Reglan that may be best for you.
Patients with liver and kidney problems may require a dose adjustment.
Ingredients
Metoclopramide is the active ingredient in Reglan.
Contraindications
Reglan should not be administered to patients with any of the following:
- An allergy to metoclopramide, paraben, procainamide, or to any of the other ingredients contained in Reglan
- Potentially dangerous gastrointestinal motility stimulation (e.g., gastrointestinal bleeding, obstruction, or perforation)
- Seizures or seizure disorder
- History of tardive dyskinesia or a dystonic reaction
- Pheochromocytoma or catecholamine-releasing paragangliomas
Some forms of Reglan should also be avoided in children, infants, and neonates.Cautions
The following FDA Boxed Warning is associated with Reglan:
- Tardive dyskinesia, a potentially irreversible movement disorder, can be caused by Reglan. There is no known treatment for tardive dyskinesia. The risk for tardive dyskinesia increases with longer-term Reglan treatment and total cumulative dosage.
- Reglan should be discontinued in patients who develop signs or symptoms of tardive dyskinesia.
- Reglan duration of treatment should not be more than 12 weeks due to the risk of developing tardive dyskinesia with longer-term use.
- Before you begin taking Reglan, inform your doctor of:
- All the medications you take
- Your allergies
- Your current health conditions and past medical history
- Your pregnancy or breastfeeding status
- Patients with heart disease, heart failure, or high blood pressure should use Reglan with caution.
- Reglan should not be abruptly discontinued.
- Reglan may need to be avoided by patients with depression.
- Patients should not drive, operate machinery, or participate in other hazardous activities until they know how the medication affects them.
- Geriatric patients should use the lowest effective dose of Reglan as possible.
- Reglan should be used with caution in patients with liver disease or kidney failure. Dose adjustments may be needed.
- Reglan should be used with caution in patients with a history of breast cancer.
- Reglan should be used with caution in pregnant patients. Use only if necessary.
- Reglan should be used with caution in patients who are breastfeeding.
- Malignant hyperthermia can occur with Reglan use.
Side Effects
Reglan side effects include restlessness, drowsiness, fatigue, and lack of energy. Other side effects may also occur. Call your doctor immediately if you have bothersome or persistent side effects.
You can buy Reglan medication online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
References:
- Metoclopramide. PDR.
- Reglan. Baudette, MN; ANI Pharmaceuticals, Inc.; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 5004
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