What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Rectiv Ointment (Glyceryl Trinitrate)
Prescription Required
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Product Details
Description
Rectiv ointment is a prescription medication used to treat anal fissures. It contains the active ingredient glyceryl trinitrate, which belongs to a class of drugs called nitrates.
Nitrates work by relaxing the smooth muscles in the anal area and increasing blood flow, which can help reduce pain and promote healing.
Fact Table
Formula
C3H5N3O9
License
US FDA
Bioavailability
Less than 1%
Legal status
Rx-Only
Chemical Name
Glyceryl trinitrate
Elimination half-life
3 minutes
Dosage (Strength)
0.4% 30 grams
Pregnancy
Consult Doctor
Brands
Rectiv
Protein binding
11-60%
PubChem CID
4510
MedlinePlus
a601086
ChEBI
28787
ATC code
C01DA02
DrugBank
DB00727
KEGG
D00515
Routes of administration
Ointment
Directions
Before using Rectiv ointment, wash the affected area with mild soap and warm water. Dry the area before applying the medicated ointment.
Apply a small amount of the medication to the affected area twice daily, in the morning and evening.
Do not use Rectiv ointment for more than 3 weeks without consulting your doctor.
Ingredients
The active ingredient in Rectiv ointment is glyceryl trinitrate. Inactive ingredients include white petrolatum and anhydrous lanolin.
Interactions
Drug interactions with Rectiv may include:
- Alcohol
- Alfuzosin
- Alteplase
- Amifostine
- Amisulpride
- Anticholinergic Agents
- Antipsychotic Agents
- Apomorphine
- Barbiturates
- Benperidol
- Blood Pressure Lowering Agents
- Brimonidine
- Bromperidol
- Dapoxetine
- Dapsone
- Diazoxide
- DULoxetine
- Ergot Derivatives
- Heparin
- Herbal Products with Blood Pressure Lowering Effects
- Hypotension-Associated Agents
- Levodopa-Containing Products
- Local Anesthetics
- Lormetazepam
- Molsidomine
- Naftopidil
- Nicergoline
- Nicorandil
- Nitric Oxide
- Nitroprusside
- Obinutuzumab
- Pentoxifylline
- Pholcodine
- Phosphodiesterase 5 Inhibitors
- Prilocaine
- Prostacyclin Analogues
- Quinagolide
- Rilmenidine
- Riociguat
- Rosiglitazone
- Sodium Nitrite
Cautions
Do not apply Rectiv ointment to broken, infected, or irritated skin. Rectiv ointment is not recommended for use in children.
Do not use Rectiv if you are allergic to glyceryl trinitrate or any other ingredient in the medication.
Side Effects
Potential adverse reactions may include:
- Abdominal pain
- Application site irritation
- Asthenia
- Contact dermatitis
- Diaphoresis
- Dizziness
- Drowsiness
- Dyspnea
- Exfoliative dermatitis
- Fixed drug eruption
- Flushing
- Headache
- Hypersensitivity reaction
- Hypotension
- Hypoxemia
- Lactic acidosis
- Methemoglobinemia
- Nausea
- Nonimmune anaphylaxis
- Orthostatic hypotension
- Pallor
- Palpitation
- Paresthesia
- Peripheral edema
- Pharyngitis
- Rebound hypertension
- Restlessness
- Rhinitis
- Shock
- Skin rash
- Syncope
- Tachycardia
- Vertigo
- Vomiting
References
Rectiv Ointment [package insert]. Bedminster, NJ: ProStrakan, Inc; 2011.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13823
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