Procardia (Nifedipine)
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Prescription Required
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Product Details
Description
Procardia is a medication prescribed primarily for hypertension and angina. Hypertension is abnormally high blood pressure, and angina is chest pain.
Hypertension, a leading cause of cardiac mortality globally, often remains undetected due to its lack of overt symptoms, while angina manifests as chest pain, making it easier for individuals to recognize.
Nifedipine, the active component of Procardia, works by blocking cardiac calcium channels, which lowers the pressure exerted on blood vessel walls. By relaxing and dilating blood vessels, Procardia facilitates smoother blood flow to reduce blood pressure and alleviate chest discomfort.
Procardia is also sometimes prescribed for Raynaud’s phenomenon.
Fact Table
Formula
C17H18N2O6
License
US FDA
Bioavailability
45-68%
Legal status
Prescription only (?)
Chemical Name
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
Elimination half-life
2-5 hours (immediate-release)
Dosage (Strength)
10 mg, 20 mg capsules (immediate-release); 30 mg, 60 mg, 90 mg tablets (extended-release)
Pregnancy
Consult a doctor
Brands
Procardia, Adalat, Nifedical
Protein binding
92-98%
PubChem CID
4485
MedlinePlus
a684028
ChEBI
CHEBI:7572
ATC code
C08CA05
DrugBank
DB01115
KEGG
D00451
Routes of administration
Oral
Directions
The starting dosage of Procardia is 30-60 mg by mouth once daily, which can be increased to a maximum of 120 mg once daily.
Ingredients
The active ingredient is nifedipine.
Interactions
Common drug-drug interactions include:
- Abametapir
- Amobarbital
- Aprobarbital
- Armodafinil
- Atazanavir
- Boceprevir
- Bosentan
- Butabarbital
- Butalbital
- Carbamazepine
- Ceritinib
- Clarithromycin
- Clobazam
- Clopidogrel
- Cobicistat
- Conivaptan
- Cyclosporine
- Dantrolene
- Darunavir
- Dexamethasone
- Digoxin
- Efavirenz
- Enzalutamide
- Epirubicin
- Erythromycin
- Etravirine
- Fedratinib
- Fentanyl
- Fexinidazole
- Fluconazole
- Fluoxetine
- Fosnetupitant
- Fosphenytoin
- Idelalisib
- Itraconazole
- Ketoconazole
- Lacosamide
- Lonafarnib
- Mavacamten
- Melphalan
- Mephobarbital
- Methohexital
- Mibefradil
- Micafungin
- Mifepristone
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant
- Nevirapine
- Omaveloxolone
- Oxcarbazepine
- Pentobarbital
- Phenobarbital
- Phenytoin
- Pioglitazone
- Posaconazole
- Prednisone
- Primidone
- Quinidine
- Repotrectinib
- Ribociclib
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Rufinamide
- Saquinavir
- Secobarbital
- St John's Wort
- Tacrolimus
- Telaprevir
- Telithromycin
- Thiopental
- Topiramate
- Troleandomycin
- Tucatinib
- Voriconazole
Cautions
Individuals with a history of heart conditions, liver disease, or kidney issues should notify their healthcare provider before starting Procardia.
Closely monitor blood pressure and heart rate when starting treatment initiation or making dose adjustments to mitigate the risk of significant blood pressure drops.
Side Effects
Adverse reactions to Procardia may include:
- Aplastic anemia
- Cough
- Dyspnea
- Dizziness
- Feeling nervous
- Flushing
- Gastrointestinal obstruction
- Gastrointestinal ulcer
- Headache
- Hypotension
- Myocardial infarction
- Nausea
- Palpitations
- Peripheral edema
- Ventricular arrhythmia
References
Procardia [package insert]. New York, NY: Pfizer; July 2013.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9493
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