What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Probenecid
Prescription Required
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Product Details
Description
Probenecid uses: Probenecid is prescribed for the treatment of gout and gouty arthritis.
Probenecid is available in 500 mg oral tablets.
Fact Table
Formula
C13H19NO4S
License
US FDA
Bioavailability
90-100%
Legal status
Prescription only (Rx)
Chemical Name
Probenecid
Elimination half-life
3-17 hours
Dosage (Strength)
500 mg tablets
Pregnancy
Consult a doctor
Brands
Benemid, Probalan
Protein binding
75-95%
PubChem CID
4913
MedlinePlus
a682395
ChEBI
CHEBI:8495
ATC code
M04AB01
DrugBank
DB01032
KEGG
D00497
Routes of administration
Oral
Directions
Take probenecid exactly as prescribed by your doctor. Your doctor will instruct you on how much probenecid you should be taking. For more instructions for use, carefully read the medication guide that accompanies your prescription.
Recommended dosing for adults: 250 mg by mouth twice a day for one week, then 500 mg by mouth twice a day thereafter.
Store probenecid tablets between 20°C and 25°C (68°F and 77°F).
If you have any questions or concerns about the medication, contact your doctor or pharmacist.
Ingredients
The active ingredient is probenecid.
Inactive ingredients include silicon dioxide, corn starch, D&C Yellow No. 10, FD&C Blue No. 2, FD&C Red No. 40, magnesium stearate, microcrystalline cellulose 101, polyethylene glycol 4000, polyvinyl alcohol, povidone K90, sodium lauryl sulfate, sodium starch glycolate type A potato, talc, and titanium dioxide.
Contraindications
Patients who meet the following criteria should not receive probenecid:
- An allergy to probenecid
- Younger than 2 years of age
- Have a blood disease/disorder or uric acid kidney stones
- Active acute gout attack
Cautions
- Before you begin taking probenecid, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Probenecid is associated with the following warnings and precautions:
- Worsening of gout after treatment
- Increased levels of methotrexate that may lead to toxicity
- Severe allergic reactions, including anaphylaxis
- Use in pregnancy: the benefits must outweigh the risks
- Blood in the urine, renal colic, costovertebral pain, and uric acid stones that can occur with probenecid treatment may be prevented by alkalizing the urine and drinking plenty of fluids
- Caution should be used in patients who have had a peptic ulcer
- Patients with kidney problems may need an adjusted dose
- A reducing substance may be seen in the urine, which will go away once therapy is stopped
Side Effects
Headache, dizziness, acute gouty arthritis, liver necrosis, vomiting, nausea, anorexia, sore gums, kidney problems, uric acid stones, renal colic, costovertebral pain, changes in urinary frequency, anaphylaxis, fever, hives, itching, anemia, blood cell count abnormalities, and skin problems are possible side effects of probenecid; however, other side effects may also occur. Immediately tell your doctor about any side effects that bother you or won’t resolve
You can buy probenecid 500 mg tablets right here.
Reference
Probenecid. 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13812
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