What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Piqray (Alpelisib)
Prescription Required
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Product Details
Description
Piqray (alpelisib) is an oral medication prescribed to treat adults with:
- hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, breast cancer that has advanced or spread to other parts of the body and has progressed during or after receiving endocrine-based treatment
Piqray is available in 50 mg, 150 mg, and 200 mg tablets.
Fact Table
Formula
C19H22F3N5O2
License
US FDA
Bioavailability
N/A (Oral administration)
Legal status
Prescription only
Chemical Name
Alpelisib
Elimination half-life
8-13 hours
Dosage (Strength)
50 mg, 150 mg, 200 mg tablets
Pregnancy
Consult a doctor
Brands
Piqray
Protein binding
89%
PubChem CID
25141694
MedlinePlus
a619020
ChEBI
63631
ATC code
L01XX53
DrugBank
DB12059
KEGG
D10454
Routes of administration
Oral
Directions
Take Piqray exactly as prescribed by your doctor. Carefully read the medication guide that comes with your prescription.
Piqray dosing:
Your doctor will tell you how much Piqray you should take. The recommended dose is 300 mg by mouth one time a day with food.
Piqray storage:
Keep Piqray tablets at room temperature between 68°F and 77°F (20°C and 25°C).
Keep the medication out of reach of children.
If you have any questions or concerns regarding Piqray treatment, contact your doctor or pharmacist.
Ingredients
The active ingredient in Piqray is alpelisib.
Inactive ingredients include hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, and sodium starch glycolate. The film-coating contains hypromellose, iron oxide black, iron oxide red, macrogol/polyethylene glycol (PEG) 4000, talc, and titanium dioxide.
Contraindications
Patients with an allergy to Piqray or to any of its ingredients should not take it.
Cautions
- Before you begin taking Piqray, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Piqray is associated with the following warnings and precautions:
- Severe hypersensitivity reactions
- Severe cutaneous adverse reactions
- High blood glucose
- Pneumonitis and interstitial lung disease
- Diarrhea or colitis
- Harm to an unborn baby. Effective contraception is recommended for females of childbearing age and males with female partners who are of childbearing age during treatment with Piqray and for one week after taking the final dose.
- Breastfeeding is not recommended.
Side Effects
High blood glucose; elevated creatinine; diarrhea; rash; decreased blood glucose, lymphocytes, and hemoglobin; increased gamma-glutamyl transferase (GGT), liver enzymes, and lipase; nausea; fatigue; decreased appetite; swelling/sores of the mouth; vomiting; weight loss; decreased calcium levels; hair loss; and prolonged blood clotting time are common Piqray side effects. However, other side effects may also occur. Immediately tell your doctor about any side effects that bother you or won’t go away.
You can buy Piqray right here!
Reference:
Piqray. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14551
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