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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Pamidronate Disodium (Pamidronate Disodium)
Prescription Required
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Product Details
Description
Pamidronate disodium is a bisphosphonate medication indicated to treat osteoporosis, high calcium levels during cancer, Paget’s disease, and bone metastases. All of these conditions are disorders of the bone, and pamidronate helps to restore normal bone health.
Pamidronate works by attaching to calcium phosphate crystals in the bone. By Incorporating into calcium phosphate, pamidronate prevents bone recycling and helps maintain bone health. Pamidronate also prevents the activity of osteoclasts, which are bone cells that become too active during cancer.
Fact Table
Formula
C3H9NNa2O7P2
License
US FDA
Bioavailability
N/A (administered intravenously)
Legal status
Prescription only (?)
Chemical Name
Disodium 3-amino-1-hydroxypropylidene-1,1-bisphosphonate
Elimination half-life
28.3 hours
Dosage (Strength)
30 mg, 60 mg, 90 mg vials for injection
Pregnancy
Consult a doctor
Brands
Aredia, Pamimed
Protein binding
54%
PubChem CID
46721
MedlinePlus
a601163
ChEBI
CHEBI:29353
ATC code
M05BA03
DrugBank
DB00282
KEGG
D00451
Routes of administration
Intravenous
Directions
Pamidronate disodium should only be administered by a trained healthcare professional via intravenous infusion. It is usually administered in an infusion clinic.
Your dosage will depend on the condition being treated. Take pamidronate exactly as directed by your doctor.
The maximum dosage of pamidronate per infusion is 90 mg.
Treatment should not occur more frequently than every seven days.
Your doctor may have you take calcium and vitamin D supplements between infusions.
Ingredients
The active ingredient in pamidronate is pamidronate disodium.
The inactive ingredients are mannitol and phosphoric acid.
Interactions
There are no significant drug-drug interactions between pamidronate and other medications.
Cautions
Your doctor should monitor your calcium, phosphate, magnesium, and potassium levels before and during therapy.
Tell your doctor if you have a history of thyroid problems.
Use caution if you have a history of kidney disease before starting pamidronate. This drug is removed from the body via the kidneys, so it can accumulate to dangerous levels in people with kidney disease.
See a dentist regularly while taking pamidronate to assess for jaw osteonecrosis.
Do not take pamidronate if you are pregnant or planning to become pregnant.
Side Effects
Common side effects of this drug may include:
- Anemia
- Arthralgia
- Bone pain
- Cough
- Deteriorating renal function
- Dyspnea
- Fatigue
- Focal segmental glomerulosclerosis
- Hypocalcemia
- Hypokalemia
- Hypertension
- Hypomagnesemia
- Hypophosphatemia
- Injection site disorder
- Loss of appetite
- Malaise
- Myalgia
- Nausea
- Nephrotoxicity
- Osteonecrosis of jaw
- Seizure
- Urinary tract infectious disease
- Vomiting
References
- Pamidronate [package insert]. Bedford, OH: Bedford Laboratories; January 2009.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14579
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