Description
Orencia is a prescription medication used to treat moderate to severe rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, and psoriatic arthritis. It is also used for the prevention of acute graft versus host disease (aGVHD) in patients who are at least 2 years of age and are receiving hematopoietic stem cell transplantation (HSCT).
Orencia is not recommended to be used with other medications that suppress the immune system, such as biological disease-modifying antirheumatic drugs (dMARDS) and Janus kinase (JAK) inhibitors.
Orencia is available as a subcutaneous injection in a single-dose prefilled syringe or a single-dose prefilled ClickJectâ„¢ autoinjector.
Fact Table |
Formula |
C3498H5458N922O1090S32 |
License |
US FDA, EU EMA |
Bioavailability |
78.6% |
Legal status |
Rx-Only |
Chemical Name |
Abatacept |
Elimination half-life |
13.1 days |
Dosage (Strength) |
- |
Pregnancy |
Consult Doctor |
Brands |
Orencia |
Protein binding |
- |
PubChem CID |
- |
MedlinePlus |
a606016 |
ChEBI |
- |
ATC code |
L04AA24 |
DrugBank |
DB01281 |
KEGG |
D03203 |
Routes of administration |
Intravenous, subcutaneous |
Directions
Use Orencia injection as directed by your doctor. Tell your doctor or pharmacist about any questions or concerns you may have about the medication.
If you or a caregiver will be administering your Orencia at home, your doctor will tell you or your caregiver how to prepare and inject Orencia, how much should be injected, and how often it should be injected.
Follow the storage instructions that come with your prescription. Orencia prefilled syringes and ClickJect autoinjectors should be kept out of light; refrigerated in their original containers between 36°F and 46°F (2°C and 8°C). Do not freeze and do not use it if the product is expired.
Ingredients
Abatacept, a selective T cell costimulation modulator, is the active ingredient contained in Orencia.
Dibasic sodium phosphate anhydrous, monobasic sodium phosphate monohydrate, poloxamer 188, sucrose, and water for injection are the inactive ingredients included.
Contraindications
According to Orencia’s most recent Prescribing Information, there are no known contraindications to receiving the medication.
Cautions
- Before you begin treatment with Orencia medication, talk to your doctor about:
- All the medications you take
- Your allergies
- Your health conditions and medical history
- Your pregnancy or breastfeeding status
- The risk of infections can be increased by using Orencia with TNF antagonists. Tell your doctor if you are unsure whether you take these medications.
- Orencia can cause serious allergic reactions, including anaphylaxis. Seek emergency care right away if you have trouble breathing; swelling of the face, lips, tongue, or throat; a rash; or a rapid heart rate.
- Serious infections can occur with Orencia use, especially in patients who have recurrent infections or a condition that increases their risk for infections.
- Patients should be screened for tuberculosis and viral hepatitis before starting treatment with Orencia.
- Patients should not receive live vaccines while being treated with Orencia or within 3 months of stopping Orencia.
- Patients with COPD may have more frequent respiratory issues when being treated with Orencia.
- Patients who use Orencia to prevent aGVHD may experience reactivation of cytomegalovirus and Epstein-Barr Virus.
Side Effects
Orencia can cause the following side effects: headache, upper respiratory tract infection, nasopharyngitis, and nausea. Other side effects may also occur, so be sure to tell your doctor about any bothersome or persistent side effects you experience while being treated with Orencia.
You can buy Orencia online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
Reference:
Orencia. Princeton, NJ: Bristol-Myers Squibb Company; 2021.
About Dr. Savannah Muncy (Page Author)
Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 11373