Nyvepria (Pegfilgrastim)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Nyvepria uses: Nyvepria (pegfilgrastim-apgf) helps your body make more neutrophils, which are white blood cells that help the body fight infections.
Nyvepria is available as a subcutaneous injection. It is dispensed in single-dose prefilled syringes in a 6 mg/0.6 mL concentration.
Fact Table
Formula
C845H1343N223O243S9
License
US FDA
Bioavailability
60-70%
Legal status
Prescription only
Chemical Name
Pegfilgrastim
Elimination half-life
15-80 hours
Dosage (Strength)
6 mg/0.6 mL
Pregnancy
Consult a doctor
Brands
Neulasta, Nyvepria, Ziextenzo, Lapelga
Protein binding
N/A
PubChem CID
91942286
MedlinePlus
a604002
ChEBI
63718
ATC code
L03AA13
DrugBank
DB00019
KEGG
D06464
Routes of administration
Subcutaneous
Directions
Your healthcare provider will determine an appropriate dosage for you, as well as teach your or your caregiver how to prepare, inject, and discard the medication.
Nyvepria should be injected underneath the skin of the thigh, abdomen, upper outer area of the buttocks, or outer area of the upper arm. Tell your healthcare provider or pharmacist if you have any questions or concerns.
For further instructions for use, read the medication guide that comes with your prescription.
Do not share needles or syringes with other people.
Storing Nyvepria:
Keep Nyvepria stored between 2°C and 8°C (36°F and 46°F) in the original container and away from light. Avoid freezing and shaking. If the medication is accidentally frozen, let the prefilled syringe thaw in the refrigerator before using.
Remove Nyvepria from the refrigerator 30 minutes before using so it can reach room temperature. If Nyvepria has been left at room temperature for more than 15 days, properly discard it.
Ingredients
The active ingredient in Nyvepria is pegfilgrastim-apgf. Inactive ingredients include acetate, polysorbate 20, sodium, and sorbitol in water for injection.
Contraindications
Patients with an allergy to human granulocyte colony-stimulating factors such as pegfilgrastim or filgrastim should not receive Nyvepria.
Cautions
- Before you begin treatment with Nyvepria, talk to your healthcare provider about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Nyvepria may be associated with the following:
- Splenic rupture that can be fatal. Immediately call your healthcare provider if you have pain in the left upper stomach or left shoulder.
- Acute respiratory distress syndrome. Immediately seek medical attention if you have shortness of breath, trouble breathing, or you are breathing fast.
- Serious allergic reactions, including anaphylaxis. Immediately seek medical attention if you have a rash, shortness of breath, wheezing, dizziness, swelling of your mouth or eyes, rapid heart rate, and sweating.
- Fatal sickle cell crisis. Immediately contact your healthcare provider if you have symptoms such as pain or trouble breathing.
- Glomerulonephritis, which is damage and inflammation to the part of the kidneys that is responsible for filtering the blood. Contact your healthcare provider right away if you have swelling of your face or ankles, dark urine or blood in your urine, or if you are urinating less than usual.
- Low platelet counts
- Myelodysplastic syndrome and acute myeloid leukemia. Patients with breast and lung cancer who are receiving Nyvepria along with chemotherapy and/or radiotherapy should be monitored for these conditions.
Side Effects
Bone pain and pain in the arms and legs are common Nyvepria side effects. However, other side effects may also occur. Immediately inform your healthcare provider of side effects that bother you or won’t go away.
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Reference:
Nyvepria. New York, NY: Pfizer Inc.; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14438
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