What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Noxafil (Posaconazole)
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Product Details
Description
Noxafil uses
Noxafil is an antifungal used to prevent invasive Aspergillus and Candida infections in high-risk patients, such as those who are severely immunocompromised. It is available with a valid prescription.
The oral suspension is used to treat fungal infections in the mouth and throat (thrush).
Noxafil formulations
Noxafil comes in an injection (18 mg/mL), oral tablets (100 mg), and an oral suspension (40 mg/mL).
Directions
Take Noxafil exactly as prescribed by your doctor. Carefully read the information that comes with your prescription. Talk to your doctor or pharmacist about any questions or concerns you may have.
Your doctor will determine which formulation to use, how much medication you should take, and how long your treatment will last based on the condition being treated.
Noxafil injection is typically administered by intravenous infusion over 30-90 minutes.
Noxafil tablets should be taken with food. They should not be broken, crushed, or chewed.
Noxafil oral suspension should be shaken well before use. Each dose should be taken during or within 20 minutes of a meal. If you are unable to eat a full meal, each dose should be taken with a liquid nutritional supplement or an acidic carbonated beverage.
If you miss a dose, take it as soon as you remember. However, if it’s almost time for the next dose, skip the missed dose and proceed with the regular dosing schedule. Do not double dose to make up for a missed dose.
Storage:
- Noxafil injection should be refrigerated at 36°F to 46°F (2°C to 8°C).
- Noxafil tablets should be stored at room temperature between 68°F and 77°F (20°C to 25°C).
- Noxafil oral suspension should be stored at 77°F (25°C). It should not be frozen.
Ingredients
Posaconazole is the active ingredient in Noxafil.
Inactive ingredients in the injection include 6.68 g Betadex Sulfobutyl Ether Sodium (SBECD), 0.003 g edetate disodium, hydrochloric acid and sodium hydroxide to adjust the pH to 2.6, and water for injection.
Inactive ingredients in the oral tablets include hypromellose acetate succinate, microcrystalline cellulose, hydroxypropyl cellulose, silicon dioxide, croscarmellose sodium, magnesium stearate, and Opadry® II Yellow (consists of the following ingredients: polyvinyl alcohol partially hydrolyzed, Macrogol/PEG 3350, titanium dioxide, talc, and iron oxide yellow)
Inactive ingredients in the oral suspension include polysorbate 80, simethicone, sodium benzoate, sodium citrate dihydrate, citric acid monohydrate, glycerin, xanthan gum, liquid glucose, titanium dioxide, artificial cherry flavor, and purified water.
Contraindications
Patients with an allergy to posaconazole or to any other azole antifungals should not take Noxafil. In addition, patients who are taking sirolimus, CYP3A4 substrates (pimozide and quinidine), HMG-CoA reductase inhibitors, or ergot alkaloids should not take Noxafil. Ask your doctor if you are unsure whether you are taking any of these medications.
Cautions
- Before you start treatment with Noxafil, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Noxafil increases the drug levels of cyclosporine and tacrolimus in the body; dose reductions may be needed.
- Noxafil can cause a heart arrhythmia called QTc prolongation.
- Liver enzymes can increase.
- Patients with kidney problems should not use the Noxafil injection unless the benefits outweigh the risks.
- Noxafil can prolong the hypnotic or sedative effects of midazolam. Patients should be monitored and benzodiazepine receptor antagonists should be available.
Side Effects
Diarrhea, nausea, fever, vomiting, headache, coughing, and low blood potassium levels are some Nofaxil side effects. However, these are not all the side effects that can occur. Contact your doctor right away if you have side effects that bother you or won’t go away.
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Reference
Noxafil. Whitehouse Station, NJ: Merck & Co., Inc.; 2015.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13859
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