What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ninlaro (Ixazomib)
Prescription Required
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Product Details
Description
Ninlaro is a prescribed medication for treating multiple myeloma, a type of blood cancer affecting plasma cells in the bone marrow. It is used alongside lenalidomide and dexamethasone to inhibit the growth and survival of cancerous plasma cells.
Ninlaro is prescribed by a specialist who is trained to treat cancer, called an oncologist. This medication requires careful monitoring because of the potential to cause severe side effects.
Ninlaro disrupts the growth and survival of myeloma cells by inhibiting the proteasome, a critical cellular structure responsible for protein breakdown. The proteasome is a large structure in the cell that recycles old proteins. By preventing the functioning of the proteasome, cellular trash builds up and causes cancerous cells to die.
Fact Table
Formula
C14H23BCl2N2O9
License
US FDA, EMA
Bioavailability
58% (oral)
Legal status
Prescription only (Rx)
Chemical Name
(1R)-1-[(2S)-2-[(2,5-Dichlorobenzoyl)amino]-4-methylpentanamido]-3-methylbutylboronic acid
Elimination half-life
9.5 days
Dosage (Strength)
2.3 mg, 3 mg, 4 mg oral capsules
Pregnancy
Contraindicated
Brands
Ninlaro
Protein binding
99%
PubChem CID
25141694
MedlinePlus
a616026
ChEBI
CHEBI:82728
ATC code
L01XX50
DrugBank
DB11783
KEGG
D10618
Routes of administration
Oral
Directions
Ninlaro is given along with other medications in a chemotherapy cycle. It is given on days 1, 8, and 15 of the 28-day chemotherapy cycle.
Take Ninlaro exactly as prescribed by your doctor. Only stop or adjust it after speaking with your doctor.
Ingredients
The active ingredient in Ninlaro is ixazomib.
Interactions
Some of the common drug-drug interactions may include:
- Abametapir
- Carbamazepine
- Clarithromycin
- Conivaptan
- Enzalutamide
- Fedratinib
- Fexinidazole
- Fosphenytoin
- Itraconazole
- Mavacamten
- Mitotane
- Omaveloxolone
- Phenobarbital
- Phenytoin
- Primidone
- Rifampin
- St John's Wort
Cautions
Pregnant individuals or those attempting pregnancy should refrain from taking Ninlaro.
Patients using Ninlaro should be monitored for platelet count during dose adjustments.
Tell your doctor about any severe gastrointestinal side effects, pain, numbness, tingling in hands or feet, or rash.
Side Effects
Some other drug-drug interactions may include:
- Bronchitis
- Cholestatic hepatitis
- Constipation
- Diarrhea
- Disorder of eye
- Hepatocellular liver damage
- Hepatotoxicity
- Hemolytic uremic syndrome, Thrombocytopenia, Grade 3 or 4
- Injury of liver
- Nausea
- Neutropenia, All Grades
- Peripheral edema
- Peripheral nerve disease
- Rash
- Stevens-Johnson syndrome
- Steatosis of liver
- Thrombocytopenia, All Grades
- Thrombotic thrombocytopenic purpura
- Vomiting
References
Ninlaro [package insert]. Lexington, MA: Takeda; May 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14581
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