What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Nexletol (bempedoic acid)
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Product Details
Description
Nexletol (bempedoic acid) is used with diet and statin treatment in adults with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease who need extra lowering of low-density lipoprotein cholesterol (LDL-C).
Fact Table
Formula
C19H36O5
License
US DailyMed, EU EMA
Bioavailability
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Legal status
Rx-only
Chemical Name
Bempedoic acid
Elimination half-life
21±11 hrs
Dosage (Strength)
180mg
Pregnancy
Consult Doctor
Brands
Nexletol
Protein binding
99.3%
PubChem CID
10472693
MedlinePlus
a620020
ChEBI
149601
ATC code
N02CD06
DrugBank
DB12457
KEGG
C10AX15
Routes of administration
By mouth
Directions
Nexletol is available in a 180 mg tablet.
The dose is to take one tablet by mouth once daily with or without food.
Ingredients
The active ingredient in Nexletol is bempedoic acid.
Cautions
- Before you start treatment with Nexletol, inform your doctor:
- Of any medications you take. These include prescription and over-the-counter medications, vitamins, and herbal supplements.
- Of your allergies.
- Of your medical conditions.
- If you are pregnant or plan to become pregnant.
- If you are breastfeeding or plan to breastfeed.
- Avoid taking Nexletol with more than 20 mg of simvastatin or more than 40 mg of pravastatin.
- Nexletol can cause increased uric acid levels in the blood that can lead to gout.
- Nexletol can cause tendon rupture. Stop taking Nexletol and call your doctor right away if you experience joint pain, swelling, or inflammation.
Side Effects
Nexletol can cause upper respiratory tract infection, muscle spasms, stomach pain, back pain, bronchitis, pain in extremity, anemia, and increased liver enzymes.
Tell your doctor right away if you experience negative or persistent side effects.
Reference:
Nexletol. Ann Arbor, MI: Esperion Therapeutics, Inc.; 2021.
Frequently Asked Questions about Nexletol (Bempedoic Acid)
What is Nexletol used for?
Nexletol (bempedoic acid) is used to lower LDL cholesterol in adults with certain conditions like heterozygous familial hypercholesterolemia (HeFH) or established atherosclerotic cardiovascular disease.
Does Nexletol cause hair loss?
There is no evidence to suggest that Nexletol causes hair loss, as this side effect has not been reported in clinical trials.
Does Nexletol cause weight gain?
Nexletol is not associated with weight gain, and clinical studies have not indicated weight changes as a side effect.
Is Nexletol hard on the liver?
Nexletol may cause elevated liver enzymes, suggesting possible liver stress, though significant liver damage is uncommon. Regular liver function monitoring is recommended.
Is Nexletol safe for kidneys?
Nexletol is generally considered safe for the kidneys, but individuals with severe kidney problems should consult their healthcare provider before starting the medication.
How does Nexletol work?
Nexletol works by inhibiting an enzyme called adenosine triphosphate-citrate lyase (ACL) in the liver, reducing LDL cholesterol production.
Is Nexletol a statin?
No, Nexletol is not a statin. It is an ACL inhibitor, which lowers cholesterol through a different mechanism than statins.
What are the side effects of Nexletol?
Common side effects include respiratory infections, muscle spasms, back pain, abdominal pain, bronchitis, pain in limbs, anemia, and elevated liver enzymes. Serious side effects may include gout and tendon rupture.
Does Nexletol cause memory loss?
There is no evidence to suggest that Nexletol causes memory loss; this side effect was not reported in clinical trials.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13644
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