Neptazane (Methazolamide)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Your eye doctor may prescribe Neptazane to treat glaucoma, a condition involving increased eye pressure that can lead to vision loss. Glaucoma often affects older adults and can cause symptoms like eye pain, headaches, halos around lights, decreased vision, nausea, and vomiting.
Methazolamide, the active ingredient in Neptazane, is a carbonic anhydrase inhibitor that reduces the production of aqueous humor (the fluid in the eye), lowering intraocular pressure.
Fact Table
Formula
C5H8N2O3S2
License
US FDA
Bioavailability
~100%
Legal status
Prescription only (?)
Chemical Name
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2-yl]acetamide
Elimination half-life
14 hours
Dosage (Strength)
25 mg, 50 mg tablets
Pregnancy
Not recommended
Brands
Neptazane
Protein binding
~55%
PubChem CID
4068
MedlinePlus
a682091
ChEBI
CHEBI:6796
ATC code
S01EC02
DrugBank
DB00812
KEGG
D02388
Routes of administration
Oral
Directions
The usual dosage of Neptazane is 50-100 mg by mouth 2-3 times daily with or without food.
Ingredients
The active ingredient in Neptazane is methazolamide.
Interactions
Tell your doctor and pharmacist if you are taking any of the following drugs:
- Aspirin
- Levoketoconazole
- Memantine
- Metformin
- Methotrexate
- Topiramate
Cautions
Before starting Neptazane, tell your doctor about any history of kidney or liver disease, electrolyte imbalances, or blood disorders.
Your healthcare team should regularly monitor blood electrolytes and kidney function, as methazolamide can cause significant electrolyte disturbances.
Methazolamide can also increase the risk of metabolic acidosis, especially in diabetic patients. Symptoms such as confusion, rapid heartbeat, fatigue, or rapid breathing require immediate medical attention.
Severe reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported with sulfonamide use, though they are rare. If suspected, discontinue use immediately.
Severe hematologic reactions have also been reported, including agranulocytosis and aplastic anemia.
Methazolamide can cause severe liver reactions, including fulminant hepatic necrosis. Hepatic coma may occur in patients with cirrhosis or hepatic insufficiency.
Hypersensitivity reactions may recur with sulfonamide administration.
Patients with pulmonary conditions like emphysema may experience aggravated acidosis.
Side Effects
Common adverse reactions to Neptazane can include:
- Agranulocytosis
- Aplastic anemia
- Confusion
- Diarrhea
- Disorder of taste
- Electrolyte imbalance
- Fatigue
- Fulminant liver failure
- Hepatic necrosis
- Loss of appetite
- Malaise
- Metabolic acidosis
- Myopia
- Nausea
- Neutropenia
- Paresthesia
- Polyuria
- Pure red cell aplasia
- Somnolence
- Stevens-Johnson syndrome
- Thrombocytopenia
- Tinnitus
- Toxic epidermal necrolysis
- Vomiting
References
Methazolamide [package insert]. Vaughan, Ontario: AA Pharma; July 2010.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 5365
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