What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Natazia (Estradiol Valerate/Dienogest)
Prescription Required
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Product Details
Description
Natazia (estradiol valerate and estradiol valerate/dienogest) is a combined oral contraceptive used to prevent pregnancy and to treat heavy periods.
Natazia is available in a 28-day blister pack containing the following oral tablets:
- 2 dark yellow tablets that contain 3 mg of estradiol valerate
- 5 medium red tablets that contain 2 mg of estradiol valerate and 2 mg dienogest
- 17 light yellow tablets that contain 2 mg of estradiol valerate and 3 mg dienogest
- 2 dark red tablets that contain 1 mg of estradiol valerate
- 2 white inactive tablets
Fact Table
Active Ingredients
Estradiol Valerate, Dienogest
License
US FDA
Bioavailability
3-5% (Estradiol Valerate), 91% (Dienogest)
Legal status
Prescription only (Rx)
Chemical Name
Estradiol Valerate: [(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] pentanoate; Dienogest: (17a)-17-hydroxy-3-oxo-19-norpregna-4,9-dien-21-nitrile
Elimination half-life
16 hours (Estradiol Valerate), 9-10 hours (Dienogest)
Dosage (Strength)
Estradiol Valerate (3 mg, 2 mg), Dienogest (2 mg)
Pregnancy
Contraindicated
Brands
Natazia
Protein binding
Estradiol Valerate: 95-98%, Dienogest: 90-95%
PubChem CID
Estradiol Valerate: 6550, Dienogest: 6917716
MedlinePlus
a610021
ChEBI
Estradiol Valerate: CHEBI:31509, Dienogest: CHEBI:50859
ATC code
G03AA16
DrugBank
Estradiol Valerate: DB13945, Dienogest: DB08991
KEGG
Estradiol Valerate: D01912, Dienogest: D07884
Routes of administration
Oral
Directions
Take Natazia birth control pills as prescribed by your doctor. For further instructions for use, refer to the medication guide that accompanies the product.
The recommended dose is to take one tablet by mouth once daily at the same time every day. Take the tablets in the order as directed on the blister pack. Avoid skipping or delaying your dose by more than 12 hours.
Keep Natazia stored at 25°C (77°F) and away from children’s reach.
If you have any questions or concerns about your prescription, contact your doctor or pharmacist.
Ingredients
The active ingredients in Natazia are estradiol valerate and estradiol valerate/dienogest.
Contraindications
Patients who are pregnant, have a high risk of arterial or venous thrombotic diseases, have irregular uterine bleeding that is undiagnosed, have breast cancer, or have liver disease or tumors should not take Natazia.
Cautions
- Natazia contains the following FDA Boxed Warning:
- Natazia should not be taken by women who are older than 35 and smoke.
- The risk of serious cardiovascular events from combined oral contraceptives is increased with cigarette smoking.
- Before you begin taking Natazia, tell your doctor or pharmacist about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Natazia is associated with the following warnings and precautions:
- Vascular problems
- Liver disease
- High blood pressure
- Carbohydrate and lipid metabolic impacts
- Headache
- Uterine bleeding
- CYP3A4 inducers (e.g., phenytoin, carbamazepine, rifampicin, St. John’s wort) can decrease the effects of Natazia; another combined oral contraceptive should be considered
Side Effects
Headache, breast pain, nausea, vomiting, menstrual problems, mood changes, acne, and weight gain are common Natazia side effects; however, other side effects may also occur. Immediately tell your doctor about any side effects that bother you or persist.
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Reference
Natazia. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11653
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