What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Moviprep
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Product Details
Description
MoviPrep (polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid for oral solution) is an osmotic laxative for adults that is used to clean the colon before a colonoscopy.
MoviPrep is available in 2 pouches for reconstituting in water:
- Pouch A contains 100 grams of polyethylene glycol (PEG) 3350, 7.5 grams of sodium sulfate, 2.691 grams of sodium chloride, 1.015 grams of potassium chloride, and lemon flavoring
- Pouch B contains 4.7 grams of ascorbic acid and 5.9 grams of sodium ascorbate
Fact Table
Active Ingredients
Polyethylene glycol (PEG), Sodium sulfate, Sodium ascorbate, Ascorbic acid
License
US FDA, EMA
Bioavailability
Not applicable (local effect in the GI tract)
Legal status
Prescription only (Rx)
Chemical Name
Polyethylene glycol, Sodium sulfate, Sodium ascorbate, Ascorbic acid (combination product)
Elimination half-life
Not applicable (excreted unchanged in feces)
Dosage (Strength)
Two sachets containing: Sachet A (100 g PEG 3350, 7.5 g sodium sulfate, 2.691 g sodium chloride, 1.015 g potassium chloride); Sachet B (4.7 g ascorbic acid, 5.9 g sodium ascorbate)
Pregnancy
Consult a doctor
Brands
Moviprep
Protein binding
Not applicable
PubChem CID
Polyethylene glycol: 5270816, Ascorbic acid: 54670067
MedlinePlus
a603036
ChEBI
Polyethylene glycol: CHEBI:4672, Ascorbic acid: CHEBI:29073
ATC code
A06AD10
DrugBank
Polyethylene glycol: DB09287, Ascorbic acid: DB00126
KEGG
Polyethylene glycol: D04669, Ascorbic acid: D00018
Routes of administration
Oral (solution)
Directions
Use MoviPrep as directed by your doctor. For additional instructions for use, refer to the medication guide that comes with the medication.
It is recommended to complete two doses in preparation for your colonoscopy.
Only drink clear liquids once you begin MoviPrep until after the colonoscopy. Avoid eating or drinking alcohol, milk, or any other foods and drinks that are red, purple, or contain pulp. Avoid taking other laxatives while you are taking MoviPrep. Avoid taking oral medications within 1 hour before or after starting each MoviPrep dose. Make sure you finish the second dose at least 2 hours before the colonoscopy.
After mixing MoviPrep with water, keep it stored upright in a refrigerator and use it within 24 hours.
If you have any questions or concerns, don’t hesitate to contact your doctor or pharmacist.
Ingredients
The active ingredients in Pouch A include polyethylene glycol (PEG) 3350, sodium sulfate, sodium chloride, and potassium chloride, and in Pouch B include ascorbic acid and sodium ascorbate.
The inactive ingredients in Pouch A include aspartame, acesulfame potassium, and lemon flavoring including citral, lemon oil and lime oil, maltodextrin, xanthan gum, and vitamin E.
Contraindications
Patients with gastrointestinal obstruction, perforation of the bowel, gastric retention, ileus, toxic colitis or megacolon, or an allergy to any of MoviPrep’s ingredients should not take MoviPrep.
Cautions
- Before you begin MoviPrep for colonoscopy, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- MoviPrep is associated with the following warnings and precautions:
- Fluid and electrolyte abnormalities
- Heart arrhythmias
- Seizures
- Appropriate hydration and necessary lab monitoring should be completed in patients with kidney problems or taking medications that can affect kidney function
- Colonic mucosal ulcerations
- Suspected gastrointestinal obstruction or perforation should be ruled out before administration of MoviPrep
- Patients who are at risk for aspiration should be observed
- MoviPrep should be used with caution in patients with glucose-6-phosphate dehydrogenase deficiency
- MoviPrep contains phenylalanine and may be accompanied with risks in patients who have phenylketonuria
- Allergic reactions, including anaphylaxis
Side Effects
General discomfort, nausea, stomach pain, vomiting, abdominal distension, anal discomfort, thirst, rigors, hunger, and dizziness are possible side effects of MoviPrep. Other side effects may also occur. Immediately tell your doctor about any side effects that bother you or won’t resolve.
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Reference
MoviPrep. Bridgewater, NJ: Salix Pharmaceuticals; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10357
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