What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Motilium (Domperidone)
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Product Details
Description
Motilium is a medication used to treat delayed gastric emptying that can cause symptoms like nausea, vomiting, bloating, fullness, and abdominal discomfort.
Motilium works by blocking dopamine receptors in the gastrointestinal tract, which stimulates muscle contraction and increases food movement through the stomach and intestines.
Motilium is not approved for use by the Food and Drug Administration in the United States but is available in other countries.
Fact Table
Formula
C22H24ClN5O2
License
US DailyMed
Bioavailability
Oral: 13–17%
Legal status
Rx-Only
Chemical Name
Domperidone
Elimination half-life
7–9 hours
Dosage (Strength)
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Pregnancy
Consult Doctor
Brands
Motilium
Protein binding
92%
PubChem CID
3151
MedlinePlus
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ChEBI
31515
ATC code
A03FA03
DrugBank
DB01184
KEGG
D01745
Routes of administration
By mouth
Directions
The usual dosage of Motilium is 30-40 mg by mouth three to four times daily. It should be taken 15-30 minutes before meals. It is available in 10 mg tablets.
Ingredients
The active ingredient in Motilium is domperidone.
Interactions
Common drug-drug interactions with Motilium include:
- Adagrasib
- Anticholinergic Agents
- Atazanavir
- Bromocriptine
- Ceritinib
- Clarithromycin
- Cobicistat and cobicistat-containing coformulations
- Darunavir
- Fosfomycin
- Fusidic Acid (Systemic)
- Haloperidol
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lefamulin
- Levoketoconazole
- Levoketoconazole
- Levosulpiride
- Lonafarnib
- Lopinavir
- Mifepristone
- Monoamine Oxidase Inhibitors
- Nefazodone
- Nelfinavir
- Nirmatrelvir-ritonavir
- Ombitasvir-paritaprevir-ritonavir
- Ombitasvir-paritaprevir-ritonavir plus dasabuvir
- Ondansetron
- Opioid Agonists
- Pentamidine (Systemic)
- Pimozide
- Posaconazole
- Posaconazole
- QT-prolonging Agents
- Ritonavir and ritonavir-containing coformulations
- Saquinavir
- Sertindole
- Sirolimus
- Telithromycin
- Tucatinib
- Voriconazole
Cautions
Tell your doctor if you have a history of liver disease or are currently taking medication that affects your heart rhythm. Motilium can cause changes in heart rhythm and potentially serious side effects.
Motilium is not recommended for pregnant or breastfeeding women without consulting a healthcare professional.
Motilium can cause increases in prolactin levels, which can cause low libido, headaches, breast discharge, and breast growth in males.
Side Effects
The most common adverse reactions may include:
- Abdominal cramps
- Acid regurgitation
- Asthenia
- Change in appetite
- Constipation
- Diarrhea
- Dizziness
- Galactorrhea not associated with childbirth
- Gynecomastia
- Headache
- Heartburn
- Hot flash
- Increased serum cholesterol
- Increased serum prolactin
- Increased thirst
- Insomnia
- Irritability
- Lethargy
- Migraine
- Nausea
- Nervousness
- Stomatitis
- Xerostomia
References
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10539
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