What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lumakras (Sotorasib)
Prescription Required
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Product Details
Description
Lumakras is a prescription medication for treating advanced or metastatic non-small cell lung cancer (NSCLC) with a specific genetic mutation called KRAS G12C. This mutation is present in about 13% of NSCLC cases and has historically been difficult to target with traditional treatments.
Lumakras works by inhibiting the activity of the mutated KRAS protein, which is a gene responsible for the uncontrolled growth and spread of cancer cells. Lumakras attaches to the protein made by this gene mutation, rendering the protein inactive, which inhibits cancerous cell growth.
Fact Table
Formula
C30H30F2N6O3
License
US DailyMed
Bioavailability
-
Legal status
Rx-Only
Chemical Name
Sotorasib
Elimination half-life
5 hours
Dosage (Strength)
120mg
Pregnancy
Consult Doctor
Brands
Lumakras
Protein binding
-
PubChem CID
137278711
MedlinePlus
a621036
ChEBI
178199
ATC code
L01XX73
DrugBank
DB15569
KEGG
D12055
Routes of administration
By mouth
Directions
The usual dosage is 960 mg by mouth once daily. Lumakras should be taken with or without food.
Ingredients
The active ingredient is Sotorasib.
Interactions
Common drug-drug interactions include:
- Abemaciclib
- Antihepaciviral Combination Products
- Asunaprevir
- Avacopan
- Avanafil
- Avapritinib
- Axitinib
- Bedaquiline
- Elacestrant
- Elbasvir and Grazoprevir
- Encorafenib
- Entrectinib
- Fedratinib
- Fexinidazole
- Finerenone
- Flibanserin
- Ganaxolone
- Lumateperone
- Lurbinectedin
- Mavacamten
- Mobocertinib
- Neratinib
- Nirmatrelvir and ritonavir
- Lovastatin
- Simeprevir
- Sonidegib
- Tazemetostat
- Topotecan
Cautions
Do not use Lumakras if you do not have the KRAS G12C mutation. It is not effective in treating other types of lung cancer.
Tell your healthcare provider if you have a history of lung or breathing problems before using Lumakras. The medication can cause lung inflammation, which can be serious or life-threatening.
Your healthcare provider should administer a liver function test every three weeks for the first three months of treatment.
Side Effects
Common side effects may include:
- Edema
- Skin rash
- Decreased serum albumin
- Decreased serum calcium
- Decreased serum sodium
- Abdominal pain
- Decreased appetite
- Diarrhea
- Nausea
- Vomiting
- Increase in urinary protein
- Decreased hemoglobin
- Lymphocytopenia
- Prolonged partial thromboplastin time
- Hepatotoxicity
- Increased serum alanine aminotransferase
- Increased serum alkaline phosphatase
- Increased serum aspartate aminotransferase
- Fatigue
- Arthralgia
- Musculoskeletal pain
- Cough
- Dyspnea
- Pneumonia
- Cardiac failure
- Gastric ulcer
- Interstitial pulmonary disease
- Pneumonitis
- Respiratory failure
References
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13778
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