What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lorbrena (Lorlatinib)
Prescription Required
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Product Details
Description
Your doctor may prescribe Lorbrena for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). Lobrena is prescribed with a second agent, which may be crizotinib, alectinib, and certinib.
Typically, oncologists prescribe it for cancer treatment due to its effectiveness against tumors featuring distinctive genetic mutations like ALK (anaplastic lymphoma kinase) rearrangements.
Fact Table
Formula
C21H19FN6O2
License
US FDA, EMA
Bioavailability
~81%
Legal status
Prescription only (?)
Chemical Name
3-chloro-5-{2-[(2-{6-[2-(dimethylamino)ethoxy]-3-pyridinyl}-6-fluorobenzamide
Elimination half-life
23.6 hours
Dosage (Strength)
25 mg, 100 mg tablets
Pregnancy
Not recommended
Brands
Lorbrena
Protein binding
66%
PubChem CID
49800523
MedlinePlus
a618020
ChEBI
134662
ATC code
L01XE45
DrugBank
DB11984
KEGG
D10836
Routes of administration
Oral
Directions
The usual dosage is 100 mg by mouth once daily.
Ingredients
The active ingredient in Lorbrena is lorlatinib.
Interactions
The most drug-drug interactions may include:
- Abametapir
- Acalabrutinib
- Alfentanil
- Amiodarone
- Aprepitant
- Atogepant
- Avacopan
- Avanafil
- Avapritinib
- Boceprevir
- Bosentan
- Bosutinib
- Brigatinib
- Budesonide
- Buprenorphine
- Buspirone
- Capivasertib
- Capmatinib
- Carbamazepine
- Cenobamate
- Clarithromycin
- Cobicistat
- Cobimetinib
- Codeine
- Conivaptan
- Cyclosporine
- Daridorexant
- Darifenacin
- Darunavir
- Dasatinib
- Desogestrel
- Dienogest
- Digoxin
- Dihydroergotamine
- Dofetilide
- Dronedarone
- Drospirenone
- Duvelisib
- Efavirenz
- Elacestrant
- Eletriptan
- Encorafenib
- Entrectinib
- Enzalutamide
- Eplerenone
- Erdafitinib
- Ergotamine
- Estetrol
- Estradiol
- Ethinyl Estradiol
- Ethynodiol
- Etonogestrel
- Etravirine
- Everolimus
- Fedratinib
- Felodipine
- Fentanyl
- Fexinidazole
- Finerenone
- Flibanserin
- Fluconazole
- Fluticasone
- Fosaprepitant
- Fosphenytoin
- Fruquintinib
- Gestodene
- Glasdegib
- Ibrexafungerp
- Ibrutinib
- Idelalisib
- Ifosfamide
- Indinavir
- Infigratinib
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ketoconazole
- Larotrectinib
- Lefamulin
- Lemborexant
- Lenacapavir
- Leniolisib
- Levonorgestrel
- Lomitapide
- Lopinavir
- Lovastatin
- Lumacaftor
- Lumateperone
- Lurasidone
- Maraviroc
- Mavacamten
- Medroxyprogesterone
- Mestranol
- Midazolam
- Mitapivat
- Mitotane
- Mobocertinib
- Modafinil
- Nafcillin
- Naloxegol
- Nefazodone
- Nelfinavir
- Neratinib
- Nirogacestat
- Nomegestrol
- Norelgestromin
- Norethindrone
- Norgestimate
- Norgestrel
- Olutasidenib
- Omaveloxolone
- Oxycodone
- Pacritinib
- Palovarotene
- Pemigatinib
- Perampanel
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Pirtobrutinib
- Posaconazole
- Pralsetinib
- Pretomanid
- Primidone
- Quetiapine
- Quinidine
- Quizartinib
- Repotrectinib
- Rifabutin
- Rifampin
- Rimegepant
- Ripretinib
- Ritonavir
- Saquinavir
- Segesterone
- Selpercatinib
- Selumetinib
- Sildenafil
- Simvastatin
- Sirolimus
- St John's Wort
- Tacrolimus
- Tazemetostat
- Telaprevir
- Telithromycin
- Temsirolimus
- Ticagrelor
- Tipranavir
- Tolvaptan
- Triazolam
- Ubrogepant
- Ulipristal
- Vardenafil
- Venetoclax
- Voclosporin
- Vonoprazan
- Voriconazole
- Voxelotor
- Zanubrutinib
- Zolpidem
- Zuranolone
Cautions
Ask your doctor and pharmacist for a full list of precautions that apply to you.
Side Effects
The most common side effects may include:
- Altered mental status
- Arthralgia
- Atrioventricular block
- Central nervous system finding
- Diarrhea
- Dyspnea
- Dyssomnia
- Edema
- Fatigue
- Hepatotoxicity
- Hyperglycemia
- Hyperlipidemia
- Hypertriglyceridemia
- Hypertension
- Impaired cognition
- Interstitial lung disease
- Mood swings
- Peripheral nerve disease
- Pneumonitis
- Prolonged PR interval
- Psychotic disorder
- Seizure
- Speech problem
- Weight gain
References
- Lorbrena [package insert]. New York, NY: Pfizer; November 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14576
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