Leukeran (Chlorambucil)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Leukeran (chlorambucil) is prescribed to treat certain types of cancers, including chronic lymphocytic leukemia and Hodgkin’s lymphoma. It works by slowing down or stopping cancer cell growth.
Leukeran is available in 2 mg oral tablets.
Fact Table
Formula
C14H19Cl2NO2
License
US FDA, EMA
Bioavailability
70-100% (oral)
Legal status
Prescription only (Rx)
Chemical Name
Chlorambucil
Elimination half-life
1.5 hours
Dosage (Strength)
2 mg tablets
Pregnancy
Contraindicated
Brands
Leukeran
Protein binding
>99%
PubChem CID
2708
MedlinePlus
a682899
ChEBI
CHEBI:28915
ATC code
L01AA02
DrugBank
DB00577
KEGG
D07500
Routes of administration
Oral
Directions
Take Leukeran exactly as prescribed by your doctor. For additional instructions for use, read the medication guide that accompanies your prescription.
Your doctor will determine an appropriate treatment regimen for you based on the condition being treated, your weight, and your response to the medication. Leukeran is generally taken by mouth once daily.
Keep Leukeran stored in the refrigerator and avoid freezing. Keep the medication away from children and pets.
If you have any questions or concerns about Leukeran, talk to your doctor or pharmacist.
Ingredients
The active ingredient in Leukeran is chlorambucil.
Contraindications
Patients with an allergy or resistance to Leukeran medication should not take it.
Cautions
- Leukeran contains the following FDA Boxed Warning:
- Severe suppression of the bone marrow may occur.
- Long-term therapy with Leukeran may cause myelocytic leukemia and secondary cancers.
- Infertility and fetal abnormalities can occur with Leukeran.
- Before you begin treatment with Leukeran, tell your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Leukeran is associated with the following cautions:
- Seizure history, head trauma, or those taking medications that can cause epilepsy
- Potentially cancer-causing
- Potentially harmful to an unborn baby; Leukeran should not be taken while pregnant. Effective birth control methods should be used while receiving Leukeran
- Infertility can occur
- Severe bone marrow suppression can occur
- Lower doses may be required in patients with liver failure or preexisting situations of bone marrow suppression or if white blood cell counts or platelets drop below normal
- If taken within 4 weeks of radiation or chemotherapy
- Be cautious of cross-hypersensitivity with other medications that are in the same drug class as Leukeran
Side Effects
Low blood cell counts, seizures, nausea, and vomiting are possible Leukeran side effects; however, other side effects may also occur. Immediately tell your doctor if you have side effects that bother you or won’t go away.
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References
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2445
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